Biology:CDS2
 Generic protein structure example |
Phosphatidate cytidylyltransferase 2 is an enzyme that in humans is encoded by the CDS2 gene.[1][2][3]
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin.[4][5] and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (CDS1) and a second (this gene) to 20p13.[6]
References
- ↑ "Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes". Genomics 54 (1): 140–4. Nov 1998. doi:10.1006/geno.1998.5547. PMID 9806839.
- ↑ "Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene". Genomics 55 (1): 68–77. Jan 1999. doi:10.1006/geno.1998.5610. PMID 9889000.
- ↑ "Entrez Gene: CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8760.
- ↑ "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters 579 (10): 2161–5. Apr 2005. doi:10.1016/j.febslet.2005.03.007. PMID 15811335.
- ↑ "Characterization of the Cardiolipin Synthase from Arabidopsis thaliana". Ph.D. Thesis, RWTH-Aachen University. 2006. http://darwin.bth.rwth-aachen.de/opus/volltexte/2006/1629/. Retrieved 2011-07-11.
- ↑ "Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1040.
External links
- Human CDS2 genome location and CDS2 gene details page in the UCSC Genome Browser.
Further reading
- "The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content". The Journal of Biological Chemistry 272 (52): 33402–9. Dec 1997. doi:10.1074/jbc.272.52.33402. PMID 9407135.
- "Genomic organization of human CDS2 and evaluation as a candidate gene for corneal hereditary endothelial dystrophy 2 on chromosome 20p13". Experimental Eye Research 75 (5): 619–23. Nov 2002. doi:10.1006/exer.2002.2052. PMID 12457874.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. Nov 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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