From HandWiki
cytochrome P450, family 11, subfamily c, polypeptide 1
OrganismDanio rerio
RefSeq (mRNA)NM_001080204.1
RefSeq (Prot)NP_001073673.1
Other data
EC number1.14.15.4
Chromosome16: 54.46 - 54.48 Mb

The Cyp11c1 is a fish gene encoding a CYP450 enzyme, which was originally found in Zebrafish (Danio rerio), this enzyme mainly catalyze the formation of cortisol and 11-Ketotestosterone (11-KT).[1] 11-KT is the endogenous androgen in zebrafish.[2] CYP11C is the orthologous to CYP11B, tetrapod's CYP11B1 evolved from CYP11C1 of fish, and CYP11B/11C are the ohonologues to CYP11A, which duplicated during 2R event.[3]


  1. "Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction". Endocrinology 161 (6). June 2020. doi:10.1210/endocr/bqaa048. PMID 32222764. 
  2. "Loss of Cyp11c1 causes delayed spermatogenesis due to the absence of 11-ketotestosterone". The Journal of Endocrinology 244 (3): 487–499. March 2020. doi:10.1530/JOE-19-0438. PMID 31910154. 
  3. "The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 368 (1612): 20120474. February 2013. doi:10.1098/rstb.2012.0474. PMID 23297357.