Biology:Cholest-4-en-3-one 26-monooxygenase
From HandWiki
Short description: Class of enzymes
| Cholest-4-en-3-one 26-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.141 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Cholest-4-en-3-one 26-monooxygenase (EC 1.14.13.141, CYP125, CYP125A1, cholest-4-en-3-one 27-monooxygenase) is an enzyme with systematic name cholest-4-en-3-one,NADH:oxygen oxidoreductase (26-hydroxylating).[1][2][3][4] This enzyme catalyses the following chemical reaction
- cholest-4-en-3-one + NADH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] 26-hydroxycholest-4-en-3-one + NAD+ + H2O
Cholest-4-en-3-one 26-monooxygenase is a heme thiolate (P450) enzyme.
References
- ↑ "Cytochrome P450 125 (CYP125) catalyses C26-hydroxylation to initiate sterol side-chain degradation in Rhodococcus jostii RHA1". Molecular Microbiology 74 (5): 1031–43. December 2009. doi:10.1111/j.1365-2958.2009.06915.x. PMID 19843222.
- ↑ "The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection". The Journal of Biological Chemistry 284 (51): 35524–33. December 2009. doi:10.1074/jbc.M109.032706. PMID 19846552.
- ↑ "Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids". The Journal of Biological Chemistry 284 (51): 35534–42. December 2009. doi:10.1074/jbc.M109.072132. PMID 19846551.
- ↑ "Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one". Molecular Microbiology 77 (3): 730–42. August 2010. doi:10.1111/j.1365-2958.2010.07243.x. PMID 20545858.
External links
- Cholest-4-en-3-one+26-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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