Biology:D-glycero-beta-D-manno-heptose-7-phosphate kinase
From HandWiki
| D-glycero-beta-D-manno-heptose-7-phosphate kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.1.167 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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D-glycero-beta-D-manno-heptose-7-phosphate kinase (EC 2.7.1.167, heptose 7-phosphate kinase, D-beta-D-heptose 7-phosphotransferase, D-beta-D-heptose-7-phosphate kinase, HldE1 heptokinase, glycero-manno-heptose 7-phosphate kinase, D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase, hldE (gene), rfaE (gene)) is an enzyme with systematic name ATP:D-glycero-beta-D-manno-heptose 7-phosphate 1-phosphotransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- D-glycero-beta-D-manno-heptose 7-phosphate + ATP [math]\displaystyle{ \rightleftharpoons }[/math] D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP
The bifunctional protein hldE includes D-glycero-beta-D-manno-heptose-7-phosphate kinase and D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC 2.7.7.70).
References
- ↑ "Functional analysis of the glycero-manno-heptose 7-phosphate kinase domain from the bifunctional HldE protein, which is involved in ADP-L-glycero-D-manno-heptose biosynthesis". Journal of Bacteriology 187 (15): 5292–300. August 2005. doi:10.1128/jb.187.15.5292-5300.2005. PMID 16030223.
- ↑ "Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli". Journal of Bacteriology 184 (2): 363–9. January 2002. doi:10.1128/jb.184.2.363-369.2002. PMID 11751812.
- ↑ "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides". Microbiology 148 (Pt 7): 1979–89. July 2002. doi:10.1099/00221287-148-7-1979. PMID 12101286.
- ↑ "Molecular cloning and functional expression of the rfaE gene required for lipopolysaccharide biosynthesis in Salmonella typhimurium". Glycoconjugate Journal 18 (10): 779–87. October 2001. PMID 12441667.
- ↑ "Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)". Biochemistry 49 (6): 1072–81. February 2010. doi:10.1021/bi902018y. PMID 20050615.
External links
- D-glycero-beta-D-manno-heptose-7-phosphate+kinase at the US National Library of Medicine Medical Subject Headings (MeSH)
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