Biology:Diacylglycerol ethanolaminephosphotransferase

From HandWiki
Short description: Class of enzymes
ethanolaminephosphotransferase
Identifiers
EC number2.7.8.1
CAS number9026-19-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an ethanolaminephosphotransferase (EC 2.7.8.1) is an enzyme that catalyzes the chemical reaction

CDP-ethanolamine + 1,2-diacylglycerol [math]\displaystyle{ \rightleftharpoons }[/math] CMP + a phosphatidylethanolamine

Thus, the two substrates of this enzyme are CDP-ethanolamine and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylethanolamine.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase. Other names in common use include EPT, diacylglycerol ethanolaminephosphotransferase, CDPethanolamine diglyceride phosphotransferase, and phosphorylethanolamine-glyceride transferase. This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.

References

  • "The function of cytidine coenzymes in the biosynthesis of phospholipides". J. Biol. Chem. 222: 193–214. 1956. PMID 13366993.