Biology:Fucose-1-phosphate guanylyltransferase
fucose-1-phosphate guanylyltransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.7.7.30 | ||||||||
CAS number | 9033-14-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) is an enzyme that catalyzes the chemical reaction
- GTP + beta-L-fucose 1-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] diphosphate + GDP-L-fucose
Thus, the two substrates of this enzyme are GTP and beta-L-fucose 1-phosphate, whereas its two products are diphosphate and GDP-L-fucose.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:beta-L-fucose-1-phosphate guanylyltransferase. Other names in common use include GDP fucose pyrophosphorylase, guanosine diphosphate L-fucose pyrophosphorylase, GDP-L-fucose pyrophosphorylase, GDP-fucose pyrophosphorylase, and GTP:L-fucose-1-phosphate guanylyltransferase. This enzyme participates in fructose and mannose metabolism.
References
- "The metabolism of L-fucose. IV. The biosynthesis of guanosine diphosphate L-fucose in porcine liver". J. Biol. Chem. 243 (6): 1110–5. 1968. PMID 5646162.
![]() | Original source: https://en.wikipedia.org/wiki/Fucose-1-phosphate guanylyltransferase.
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