Biology:GGDEF domain

From HandWiki
GGDEF domain
PDB 1w25 EBI.jpg
response regulator PleD in complex with c-diGMP
Identifiers
SymbolGGDEF
PfamPF00990
Pfam clanCL0276
InterProIPR000160
SCOP21w25 / SCOPe / SUPFAM
CDDcd01949

In molecular biology, the GGDEF domain is a protein domain which appears to be ubiquitous in bacteria and is often linked to a regulatory domain, such as a phosphorylation receiver or oxygen sensing domain. Its function is to act as a diguanylate cyclase and synthesize cyclic di-GMP, which is used as an intracellular signalling molecule in a wide variety of bacteria.[1][2] Enzymatic activity can be strongly influenced by the adjacent domains. Processes regulated by this domain include exopolysaccharide synthesis, biofilm formation, motility and cell differentiation.

Structural studies of PleD from Caulobacter crescentus show that this domain forms a five-stranded beta sheet surrounded by helices, similar to the catalytic core of adenylate cyclase.[3]

References

This article incorporates text from the public domain Pfam and InterPro: IPR000160