Biology:Glycoside hydrolase family 25

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Glycosyl hydrolases family 25
PDB 1jfx EBI.jpg
crystal structure of the bacterial lysozyme from streptomyces coelicolor at 1.65 a resolution
Identifiers
SymbolGlyco_hydro_25
PfamPF01183
Pfam clanCL0058
InterProIPR002053
PROSITEPDOC00737
SCOP21jfx / SCOPe / SUPFAM
CAZyGH25

In molecular biology, glycoside hydrolase family 25 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]

Glycoside hydrolase family 25 CAZY GH_25 comprises enzymes with only one known activity; lysozyme (EC 3.2.1.17). It has been shown[8][9] that a number of cell-wall lytic enzymes are evolutionary related and can be classified into a single family. Two residues, an aspartate and a glutamate, have been shown[10] to be important for the catalytic activity of the Charalopsis enzyme. These residues as well as some others in their vicinity are conserved in all proteins from this family.

References

  1. "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America 92 (15): 7090–4. July 1995. doi:10.1073/pnas.92.15.7090. PMID 7624375. Bibcode1995PNAS...92.7090H. 
  2. "Structures and mechanisms of glycosyl hydrolases". Structure 3 (9): 853–9. September 1995. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779. 
  3. "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal 316 (Pt 2): 695–6. June 1996. doi:10.1042/bj3160695. PMID 8687420. 
  4. "Home" (in en). http://www.cazy.org/. 
  5. "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research 42 (Database issue): D490-5. January 2014. doi:10.1093/nar/gkt1178. PMID 24270786. 
  6. "Glycoside Hydrolase Family 25" (in en). http://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_25. 
  7. CAZypedia Consortium (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology 28 (1): 3–8. doi:10.1093/glycob/cwx089. PMID 29040563. https://hal.archives-ouvertes.fr/hal-01886461/file/Hehemann_2018_01.pdf. 
  8. "A classification of glycosyl hydrolases based on amino acid sequence similarities". The Biochemical Journal 280 (2): 309–16. December 1991. doi:10.1042/bj2800309. PMID 1747104. 
  9. "Sequence of the lyc gene encoding the autolytic lysozyme of Clostridium acetobutylicum ATCC824: comparison with other lytic enzymes". Gene 104 (1): 25–31. July 1991. doi:10.1016/0378-1119(91)90460-S. PMID 1916274. 
  10. "The N,O-diacetylmuramidase of Chalaropsis species. Identificaiton of aspartyl and glutamyl residues in the active site". The Journal of Biological Chemistry 253 (19): 6787–93. October 1978. doi:10.1016/S0021-9258(17)37988-7. PMID 567645. 
This article incorporates text from the public domain Pfam and InterPro: IPR002053