Biology:Glycoside hydrolase family 59
| Glycosyl hydrolase family 59 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Glyco_hydro_59 | ||||||||
| Pfam | PF02057 | ||||||||
| Pfam clan | CL0058 | ||||||||
| InterPro | IPR001286 | ||||||||
| OPM superfamily | 117 | ||||||||
| OPM protein | 3zr5 | ||||||||
| CAZy | GH59 | ||||||||
| |||||||||
In molecular biology, glycoside hydrolase family 59 is a family of glycoside hydrolases.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]
Glycoside hydrolase family 59 CAZY GH_59 comprises enzymes with only one known activity; galactocerebrosidase (EC 3.2.1.46). Globoid cell leukodystrophy (Krabbe disease) is a severe, autosomal recessive disorder that results from deficiency of galactocerebrosidase (GALC) activity.[8][9][10] GALC is responsible for the lysosomal catabolism of certain galactolipids, including galactosylceramide and psychosine.[8]
References
- ↑ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America 92 (15): 7090–4. July 1995. doi:10.1073/pnas.92.15.7090. PMID 7624375. Bibcode: 1995PNAS...92.7090H.
- ↑ "Structures and mechanisms of glycosyl hydrolases". Structure 3 (9): 853–9. September 1995. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
- ↑ "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal 316 ( Pt 2) (Pt 2): 695–6. June 1996. doi:10.1042/bj3160695. PMID 8687420.
- ↑ "Home" (in en). http://www.cazy.org/.
- ↑ "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research 42 (Database issue): D490-5. January 2014. doi:10.1093/nar/gkt1178. PMID 24270786.
- ↑ "Glycoside Hydrolase Family 59" (in en). http://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_59.
- ↑ CAZypedia Consortium (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology 28 (1): 3–8. doi:10.1093/glycob/cwx089. PMID 29040563. https://hal.archives-ouvertes.fr/hal-01886461/file/Hehemann_2018_01.pdf.
- ↑ 8.0 8.1 "Cloning of the canine GALC cDNA and identification of the mutation causing globoid cell leukodystrophy in West Highland White and Cairn terriers". Genomics 33 (3): 457–462. 1996. doi:10.1006/geno.1996.0220. PMID 8661004.
- ↑ "Structure and organization of the human galactocerebrosidase (GALC) gene". Genomics 26 (2): 407–409. 1995. doi:10.1016/0888-7543(95)80230-J. PMID 7601472.
- ↑ "Human galactocerebrosidase gene: promoter analysis of the 5'-flanking region and structural organization". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1395 (1): 62–67. 1998. doi:10.1016/S0167-4781(97)00140-1. PMID 9434153.
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