Biology:Glycoside hydrolase family 83

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Hemagglutinin-neuraminidase
PDB 1usr EBI.jpg
Structure of the sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase.[1]
Identifiers
SymbolHN
PfamPF00423
Pfam clanCL0434
InterProIPR000665
SCOP21usr / SCOPe / SUPFAM

In molecular biology, glycoside hydrolase family 83 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[2][3][4] This classification is available on the CAZy web site,[5][6] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[7][8]

Glycoside hydrolase family 83 CAZY GH_83 includes enzymes with neuraminidase EC 3.2.1. activity.[9]

References

  1. "Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion". J. Virol. 78 (7): 3733–41. April 2004. doi:10.1128/JVI.78.7.3733-3741.2004. PMID 15016893. 
  2. "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America 92 (15): 7090–4. July 1995. doi:10.1073/pnas.92.15.7090. PMID 7624375. 
  3. "Structures and mechanisms of glycosyl hydrolases". Structure 3 (9): 853–9. September 1995. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779. 
  4. "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal 316 ( Pt 2) (Pt 2): 695–6. June 1996. PMID 8687420. 
  5. "Home" (in en). http://www.cazy.org/. 
  6. "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research 42 (Database issue): D490–5. January 2014. doi:10.1093/nar/gkt1178. PMID 24270786. https://academic.oup.com/nar/article/42/D1/D490/1057423. 
  7. "Glycoside Hydrolase Family 83" (in en). http://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_83. 
  8. "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology 28 (1): 3–8. December 2018. doi:10.1093/glycob/cwx089. PMID 29040563. 
  9. "Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose.". Structure 13 (5): 803–15. 2005. doi:10.1016/j.str.2005.02.019. PMID 15893670. https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15893670.