Biology:Hygromycin-B kinase
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hygromycin B kinase | |||||||||
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Identifiers | |||||||||
EC number | 2.7.1.119 | ||||||||
CAS number | 88361-67-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a hygromycin-B kinase (EC 2.7.1.119) is an enzyme that catalyzes the chemical reaction
- ATP + hygromycin B [math]\displaystyle{ \rightleftharpoons }[/math] ADP + 7"-O-phosphohygromycin
Thus, the two substrates of this enzyme are ATP and hygromycin B, whereas its two products are ADP and 7-O-phosphohygromycin.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:hygromycin-B 7"-O-phosphotransferase. This enzyme is also called hygromycin B phosphotransferase.
References
- "Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus". Eur. J. Biochem. 162 (2): 419–22. 1987. doi:10.1111/j.1432-1033.1987.tb10618.x. PMID 3026811.
- "Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus - the producing organism". J. Gen. Microbiol. 131 (6): 1289–1298. 1985. doi:10.1099/00221287-131-6-1289. PMID 2995542.
Original source: https://en.wikipedia.org/wiki/Hygromycin-B kinase.
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