Biology:Inositol-hexakisphosphate kinase
From HandWiki
Short description: Class of enzymes
| Inositol-hexakisphosphate kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.4.21 | ||||||||
| CAS number | 176898-37-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Inositol-hexakisphosphate kinase (EC 2.7.4.21, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase) is an enzyme with systematic name ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- (1) ATP + 1D-myo-inositol hexakisphosphate(Phytic acid) [math]\displaystyle{ \rightleftharpoons }[/math] ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
- (2) ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [math]\displaystyle{ \rightleftharpoons }[/math] ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown)
Three mammalian isoforms are known to exist.
See also
- IHPK1
- IHPK2
References
- ↑ "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Current Biology 9 (22): 1323–6. November 1999. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768.
- ↑ "PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase". FEBS Letters 461 (3): 169–72. November 1999. doi:10.1016/S0014-5793(99)01462-3. PMID 10567691.
- ↑ "Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells". The Biochemical Journal 327 ( Pt 2) (2): 553–60. October 1997. doi:10.1042/bj3270553. PMID 9359429.
External links
- Inositol-hexakisphosphate+kinase at the US National Library of Medicine Medical Subject Headings (MeSH)
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