Biology:Inositol-pentakisphosphate 2-kinase
From HandWiki
| Inositol-pentakisphosphate 2-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.1.158 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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In enzymology, an inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) is an enzyme that catalyzes the chemical reaction
- ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [math]\displaystyle{ \rightleftharpoons }[/math] ADP + 1D-myo-inositol hexakisphosphate
Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 1,3,4,5,6-pentakisphosphate, whereas its two products are ADP and 1D-myo-inositol hexakisphosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase. Other names in common use include IP5 2-kinase, Gsl1p, Ipk1p, inositol polyphosphate kinase, inositol 1,3,4,5,6-pentakisphosphate 2-kinase, and Ins(1,3,4,5,6)P5 2-kinase.
References
- "A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export". Science 285 (5424): 96–100. 1999. doi:10.1126/science.285.5424.96. PMID 10390371.
- "Purification and some properties of inositol 1,3,4,5,6-Pentakisphosphate 2-kinase from immature soybean seeds". J. Biol. Chem. 269 (45): 28393–9. 1994. PMID 7961779.
- "Additions and corrections to Purification and some properties of inositol 1,3,4,5,6-pentakisphosphate 2-kinase from immature soybean seeds". J. Biol. Chem. 270 (13): 7782. 1997. doi:10.1074/jbc.270.13.7782.
- "Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation". Biochem. J. 335: 671–9. PMID 9794810.
- "Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway". J. Biol. Chem. 279 (49): 51022–32. 2004. doi:10.1074/jbc.M409394200. PMID 15459192.
- "Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases". J. Biol. Chem. 277 (45): 42711–8. 2002. doi:10.1074/jbc.M209112200. PMID 12226109.
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