Biology:Inositol-tetrakisphosphate 5-kinase

From HandWiki
inositol tetrakisphosphate 5-kinase
Identifiers
EC number2.7.1.140
CAS number123940-40-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an inositol-tetrakisphosphate 5-kinase (EC 2.7.1.140) is an enzyme that catalyzes the chemical reaction

ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate [math]\displaystyle{ \rightleftharpoons }[/math] ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 1,3,4,6-tetrakisphosphate, whereas its two products are ADP and 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase. This enzyme is also called 1D-myo-inositol-tetrakisphosphate 5-kinase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

References

  • Shears SB (1989). "The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase". J. Biol. Chem. 264 (33): 19879–86. PMID 2584198. 
  • "Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases". J. Biol. Chem. 277 (45): 42711–8. 2002. doi:10.1074/jbc.M209112200. PMID 12226109.