Biology:Inositol monophosphatase 2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene.[1][2] IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.
The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.[3]
References
- ↑ "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol Psychiatry 2 (5): 393–97. Nov 1997. doi:10.1038/sj.mp.4000325. PMID 9322233.
- ↑ "Entrez Gene: IMPA2 inositol(myo)-1(or 4)-monophosphatase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3613.
- ↑ "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. January 2007. doi:10.1074/jbc.M604474200. PMID 17068342.
Further reading
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- Yoshikawa T; Padigaru M; Karkera JD; Sharma, M; Berrettini, W H; Esterling, L E; Detera-Wadleigh, S D (2000). "Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2)". Mol. Psychiatry 5 (2): 165–71. doi:10.1038/sj.mp.4000688. PMID 10822344.
- Sjøholt G; Gulbrandsen AK; Løvlie R; Berle, JØ; Molven, A; Steen, V M (2000). "A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients". Mol. Psychiatry 5 (2): 172–80. doi:10.1038/sj.mp.4000681. PMID 10822345.
- Yoon IS; Li PP; Siu KP; Kennedy, J L; Cooke, R G; Parikh, S V; Warsh, J J (2002). "Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder". Mol. Psychiatry 6 (6): 678–83. doi:10.1038/sj.mp.4000901. PMID 11673796.
- Strausberg RL; Feingold EA; Grouse LH; Derge, JG; Klausner, RD; Collins, FS; Wagner, L; Shenmen, CM et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster". RNA 9 (12): 1532–41. 2004. doi:10.1261/rna.5143303. PMID 14624008.
- Sjøholt G; Ebstein RP; Lie RT; Berle, J Ø; Mallet, J; Deleuze, J F; Levinson, D F; Laurent, C et al. (2005). "Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder". Mol. Psychiatry 9 (6): 621–9. doi:10.1038/sj.mp.4001460. PMID 14699425.
- Gerhard DS; Wagner L; Feingold EA; Shenmen, CM; Grouse, LH; Schuler, G; Klein, SL; Old, S et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Nakayama J; Yamamoto N; Hamano K; Iwasaki, N; Ohta, M; Nakahara, S; Matsui, A; Noguchi, E et al. (2005). "Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18". Neurology 63 (10): 1803–7. doi:10.1212/01.wnl.0000144499.34164.e0. PMID 15557493.
- Ohnishi T; Ohba H; Seo KC; Im, J.; Sato, Y.; Iwayama, Y.; Furuichi, T.; Chung, S.-K. et al. (2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342.
- Ohnishi T; Yamada K; Ohba H; Iwayama, Yoshimi; Toyota, Tomoko; Hattori, Eiji; Inada, Toshiya; Kunugi, Hiroshi et al. (2007). "A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription". Neuropsychopharmacology 32 (8): 1727–37. doi:10.1038/sj.npp.1301307. PMID 17251911.
- Arai R; Ito K; Ohnishi T; Ohba, Hisako; Akasaka, Ryogo; Bessho, Yoshitaka; Hanawa-Suetsugu, Kyoko; Yoshikawa, Takeo et al. (2007). "Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures". Proteins 67 (3): 732–42. doi:10.1002/prot.21299. PMID 17340635.
- "Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients". Eur. J. Neurol. 14 (4): 424–7. 2007. doi:10.1111/j.1468-1331.2007.01702.x. PMID 17388992.
External links
- Overview of all the structural information available in the PDB for UniProt: O14732 (Human Inositol monophosphatase 2) at the PDBe-KB.
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