Biology:MRNA guanylyltransferase

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In enzymology, a mRNA guanylyltransferase (EC is an enzyme that catalyzes the chemical reaction

GTP + (5')ppPur-mRNA [math]\rightleftharpoons[/math] diphosphate + G(5')pppPur-mRNA

Thus, the two substrates of this enzyme are GTP and (5')ppPur-mRNA, whereas its two products are diphosphate and G(5')pppPur-mRNA.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:mRNA guanylyltransferase. Other names in common use include mRNA capping enzyme, messenger RNA guanylyltransferase, and Protein 2.

Structural studies[edit]

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1CKM, 1CKN, 1CKO, 1P16, and 2C46.

References[edit] guanylyltransferase was the original source. Read more.