Biology:Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

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Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase
Identifiers
EC number3.2.1.114
CAS number82047-77-6
Alt. namesmannosidase II, exo-1,3-1,6-α-mannosidase, α-D-mannosidase II, α-mannosidase II, α-3,6-mannosidase, GlcNAc transferase I-dependent α1,3[α1,6]mannosidase, Golgi α-mannosidase II, ManII, 1,3(1,6)-α-D-mannosidase, 1,3-(1,6-)mannosyl-oligosaccharide α-D-mannohydrolase
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase, also known as Golgi α-mannosidase II, is an enzyme with systematic name (1→3)-(1→6)-mannosyl-oligosaccharide α-D-mannohydrolase.[1][2][3][4] It catalyses the hydrolysis of the terminal (1→3)- and (1→6)-linked α-D-mannose residues in the mannosyl-oligosaccharide Man5(GlcNAc)3.

This enzyme is involved in the synthesis of glycoproteins. It is a key enzyme of N-linked glycan processing and is inhibited by small molecule swainsonine.[5]

References

  1. "Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi α-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: α-D-mannoside β 2-N-acetylglucosaminyltransferase I". The Journal of Biological Chemistry 255 (10): 4894–902. May 1980. PMID 6445359. 
  2. "α-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates". The Journal of Biological Chemistry 257 (7): 3660–8. Apr 1982. PMID 7061502. 
  3. "Purification and characterization of α-D-mannosidase from rat liver Golgi membranes". The Journal of Biological Chemistry 252 (10): 3227–33. May 1977. PMID 863880. 
  4. "The production, purification and characterisation of two novel α-D-mannosidases from Aspergillus phoenicis". Carbohydrate Research 340 (4): 609–17. Mar 2005. doi:10.1016/j.carres.2005.01.005. PMID 15721331. 
  5. "Structure of Golgi α-mannosidase II: a target for inhibition of growth and metastasis of cancer cells". The EMBO Journal 20 (12): 3008–3017. 2001. doi:10.1093/emboj/20.12.3008. PMID 11406577. 

External links