Biology:N-acylmannosamine kinase
N-acylmannosamine kinase | |||||||||
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![]() N-acetylmannosamine kinase dimer, Human | |||||||||
Identifiers | |||||||||
EC number | 2.7.1.60 | ||||||||
CAS number | 9027-53-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a N-acylmannosamine kinase (EC 2.7.1.60) is an enzyme that catalyzes the chemical reaction
- ATP + N-acyl-D-mannosamine [math]\displaystyle{ \rightleftharpoons }[/math] ADP + N-acyl-D-mannosamine 6-phosphate
Thus, the two substrates of this enzyme are ATP and N-acyl-D-mannosamine, whereas its two products are ADP and N-acyl-D-mannosamine 6-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-acyl-D-mannosamine 6-phosphotransferase. Other names in common use include acylmannosamine kinase (phosphorylating), acetylamidodeoxymannokinase, acetylmannosamine kinase, acylaminodeoxymannokinase, acylmannosamine kinase, N-acyl-D-mannosamine kinase, N-acetylmannosamine kinase, and ATP:N-acetylmannosamine 6-phosphotransferase. This enzyme participates in aminosugars metabolism.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2AA4.
References
- "Purification and properties of N-acetylmannosamine kinase from Salmonella typhimurium". Eur. J. Biochem. 8 (2): 200–6. 1969. doi:10.1111/j.1432-1033.1969.tb00515.x. PMID 4889177.
- "Enzymatic phosphorylation of N-acetyl-D-mannosamine". Proc. Natl. Acad. Sci. U.S.A. 47 (7): 955–8. 1961. doi:10.1073/pnas.47.7.955. PMID 13704957.
- "The sialic acids. VII. N-acyl-D-mannosamine kinase from rat liver". J. Biol. Chem. 241 (23): 5619–26. 1966. doi:10.1016/S0021-9258(18)96389-1. PMID 5928201.
![]() | Original source: https://en.wikipedia.org/wiki/N-acylmannosamine kinase.
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