Biology:Phosphoenolpyruvate—protein phosphotransferase
| phosphoenolpyruvate-protein phosphotransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.7.3.9 | ||||||||
| CAS number | 37278-17-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) is an enzyme that catalyzes the chemical reaction
- phosphoenolpyruvate + protein histidine [math]\displaystyle{ \rightleftharpoons }[/math] pyruvate + protein Npi-phospho-L-histidine
Thus, the two substrates of this enzyme are phosphoenolpyruvate and protein histidine, whereas its two products are pyruvate and protein Npi-phospho-L-histidine.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a nitrogenous group as acceptor. This enzyme participates in phosphotransferase system (pts).
Nomenclature
The systematic name of this enzyme class is phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase. Other names in common use include phosphoenolpyruvate sugar phosphotransferase enzyme I, phosphopyruvate-protein factor phosphotransferase, phosphopyruvate-protein phosphotransferase, sugar-PEP phosphotransferase enzyme I, and phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase.
References
- "The bacterial phosphoenolpyruvate: sugar phosphotransferase system". Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes 457 (3–4): 213–57. December 1976. doi:10.1016/0304-4157(76)90001-0. PMID 187249.
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