Biology:Phosphoenolpyruvate—protein phosphotransferase

From HandWiki
Short description: Enzyme
phosphoenolpyruvate-protein phosphotransferase
Identifiers
EC number2.7.3.9
CAS number37278-17-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) is an enzyme that catalyzes the chemical reaction

phosphoenolpyruvate + protein histidine [math]\displaystyle{ \rightleftharpoons }[/math] pyruvate + protein Npi-phospho-L-histidine

Thus, the two substrates of this enzyme are phosphoenolpyruvate and protein histidine, whereas its two products are pyruvate and protein Npi-phospho-L-histidine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a nitrogenous group as acceptor. This enzyme participates in phosphotransferase system (pts).

Nomenclature

The systematic name of this enzyme class is phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase. Other names in common use include phosphoenolpyruvate sugar phosphotransferase enzyme I, phosphopyruvate-protein factor phosphotransferase, phosphopyruvate-protein phosphotransferase, sugar-PEP phosphotransferase enzyme I, and phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase.

References

  • "The bacterial phosphoenolpyruvate: sugar phosphotransferase system". Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes 457 (3–4): 213–57. December 1976. doi:10.1016/0304-4157(76)90001-0. PMID 187249.