Biology:Protein-fructosamine 3-kinase
From HandWiki
| Protein-fructosamine 3-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.1.171 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Protein-fructosamine 3-kinase (EC 2.7.1.171, FN3K, fructosamine 3-kinase) is an enzyme with systematic name ATP:(protein)-N6-D-fructosyl-L-lysine 3-phosphotransferase.[1][2] This enzyme catalyses the following chemical reaction
- ATP + [protein]-N6-D-fructosyl-L-lysine [math]\displaystyle{ \rightleftharpoons }[/math] ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
Nonenzymatic glycation is a factor in the pathogenesis of diabetes.
References
- ↑ "Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo". Diabetes 50 (9): 2139–47. September 2001. doi:10.2337/diabetes.50.9.2139. PMID 11522682.
- ↑ "Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase". Diabetes 49 (10): 1627–34. October 2000. doi:10.2337/diabetes.49.10.1627. PMID 11016445.
External links
- Protein-fructosamine+3-kinase at the US National Library of Medicine Medical Subject Headings (MeSH)
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