Biology:Protein-ribulosamine 3-kinase

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Protein-ribulosamine 3-kinase
Identifiers
EC number2.7.1.172
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Protein-ribulosamine 3-kinase (EC 2.7.1.172, FN3KRP, FN3K-related protein, FN3K-RP, ketosamine 3-kinase 2, fructosamine-3-kinase-related protein, ribulosamine/erythrulosamine 3-kinase, ribulosamine 3-kinase) is an enzyme with systematic name ATP:(protein)-N6-D-ribulosyl-L-lysine 3-phosphotransferase.[1][2][3] This enzyme catalyses the following chemical reaction

ATP + [protein]-N6-D-ribulosyl-L-lysine [math]\displaystyle{ \rightleftharpoons }[/math] ADP + [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine

This enzyme takes part in freeing proteins from ribulosamines or psicosamines.

References

  1. "A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines". Diabetes 52 (12): 2888–95. December 2003. doi:10.2337/diabetes.52.12.2888. PMID 14633848. 
  2. "Plant ribulosamine/erythrulosamine 3-kinase, a putative protein-repair enzyme". The Biochemical Journal 388 (Pt 3): 795–802. June 2005. doi:10.1042/BJ20041976. PMID 15705060. 
  3. "Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine". The Biochemical Journal 416 (2): 281–8. December 2008. doi:10.1042/BJ20080389. PMID 18637789. 

External links