Biology:UDP-N-acetylglucosamine diphosphorylase
| UDP-N-acetylglucosamine diphosphorylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 N-acetyl glucosamine 1-phosphate uridyltransferase homotrimer, Mycobacterium tuberculosis | |||||||||
| Identifiers | |||||||||
| EC number | 2.7.7.23 | ||||||||
| CAS number | 9023-06-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an UDP-N-acetylglucosamine diphosphorylase (EC 2.7.7.23) is an enzyme that catalyzes the chemical reaction
- UTP + N-acetyl-alpha-D-glucosamine 1-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] diphosphate + UDP-N-acetyl-D-glucosamine
Thus, the two substrates of this enzyme are UTP and[N-acetyl-alpha-D-glucosamine 1-phosphate, whereas its two products are diphosphate and UDP-N-acetyl-D-glucosamine. This enzyme participates in aminosugars metabolism.
Nomenclature
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase. Other names in common use include UDP-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine pyrophosphorylase, UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate, uridylyltransferase, UDP-GlcNAc pyrophosphorylase, GlmU uridylyltransferase, Acetylglucosamine 1-phosphate uridylyltransferase, UDP-acetylglucosamine pyrophosphorylase, uridine diphosphate-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, and acetylglucosamine 1-phosphate uridylyltransferase.
References
- "Purification of uridine diphosphoacetylglucosamine pyrophosphorylase from sheep brain". Biochimica et Biophysica Acta 50: 129–34. June 1961. doi:10.1016/0006-3002(61)91068-X. PMID 13733356.
- "Uridine diphosphoacetylglucosamine pyrophosphorylase". J. Biol. Chem. 234 (7): 1822–1827. 1959. doi:10.1016/S0021-9258(18)69933-8. PMID 13672971.
 |  |
