Biology:Vitamin D-dependent calcium-binding protein
From HandWiki
Vitamin D-dependent calcium binding proteins were discovered in the cytosolic fractions of chicken intestine, and later in mammalian intestine and kidney, by workers including Robert Wasserman of Cornell University.[1][2] They bound calcium in the micromolar range and were greatly reduced in vitamin D-deficient animals. Expression could be induced by treating these animals with vitamin D metabolites such as calcitriol.
They were found to exist in two distinct sizes with a molecular weight of approximately 9 kDa and 28 kDa. They were renamed calbindin. Calbindin-D9k (S100G) is found in mammalian intestine and calbindin-D28k is in avian intestine and in mammalian kidney and other tissues.
See also
References
- ↑ Wasserman, RH; Taylor, AN (1966). "Vitamin D3-induced calcium-binding protein in chick intestinal mucosa.". Science 152 (3723): 791–3. doi:10.1126/science.152.3723.791. PMID 17797460.
- ↑ Wasserman, RH; Corradino, RA; Taylor, AN (1969). "Binding proteins from animals with possible transport function.". The Journal of General Physiology 54 (1): 114–37. doi:10.1085/jgp.54.1.114. PMID 19873640.
External links
- Vitamin+D-Dependent+Calcium-Binding+Protein at the US National Library of Medicine Medical Subject Headings (MeSH)
- Calcium Vitamins
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