Chemistry:1-Formyl-LSD
1-Formyl-LSD, also known as 1-formyl-N,N-diethyllysergamide and sometimes referred to as 1F-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1][2] It is the 1-formyl derivative of LSD.[1][2][3]
Another drug, 1‐(furan‐2‐carbonyl)‐LSD (SYN-L-005), has also been referred to as "1F-LSD".[3]
Use and effects
The drug is assumed to act as a prodrug of LSD.[1] It produces psychedelic effects in humans similarly to LSD.[2] Effective doses have been reported to be 100 to 150 μg orally or sublingually.[2] Very little is known about the pharmacology and properties of 1-formyl-LSD.[1]
Interactions
History
1-Formyl-LSD was first described in the scientific literature by 2021.[2] It first emerged as a novel designer drug online in January 2019.[1][2]
Society and culture
Legal status
Canada
1-Formyl-LSD is not an explicitly nor implicitly controlled substance in Canada as of 2025.[4]
United States
1-Formyl-LSD is not an explicitly controlled substance in the United States.[5] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.
See also
- Substituted lysergamide
- Lizard Labs
References
- ↑ 1.0 1.1 1.2 1.3 1.4 "1F-LSD" (in ru). https://aipsin.com/newsubstance/584/.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 "Identifying New/Emerging Psychoactive Substances at the Time of COVID-19; A Web-Based Approach". Frontiers in Psychiatry 11. 9 February 2021. doi:10.3389/fpsyt.2020.632405. ISSN 1664-0640. PMID 33633599.
- ↑ 3.0 3.1 "Analytical and Pharmacological Characterization of 1-(Furan-2-Carbonyl)-LSD (1F-LSD) and Comparison With 1-(Thiophene-2-Carbonyl)-LSD (1T-LSD)". Drug Testing and Analysis 17 (8): 1283–1293. 3 December 2024. doi:10.1002/dta.3829. ISSN 1942-7603. PMID 39624022.
- ↑ "Controlled Drugs and Substances Act". 5 December 2025. https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html.
- ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf
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