Chemistry:MAL-LAD

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MAL-LAD, or MALLAD, also known as METAL-LAD or METALLAD, as well as 6-methallyl-6-nor-LSD, is a serotonin receptor modulator of the lysergamide family related to lysergic acid diethylamide (LSD).[1][2]

The drug acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT2A receptor among others.[1][2] It is also a dopamine receptor agonist, though unlike other lysergamides, does not show activity at the dopamine D1 and D5 receptors.[2] MAL-LAD does not appear to have been assessed in animal tests of psychedelic-like activity such as drug discrimination.[1]

MAL-LAD was first described in the scientific literature by Andrew Joseph Hoffman of the lab of David E. Nichols at Purdue University by 1987.[1] It was subsequently further described by a group of researchers that included Nichols and other colleagues in 2025.[2] The drug is not a controlled substance in Canada as of 2025.[3]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 Hoffman AJ (August 1987). Synthesis and pharmacological evaluation of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives (Ph.D. thesis). Purdue University.
  2. ↑ 2.0 2.1 2.2 2.3 "The polypharmacology of psychedelics reveals multiple targets for potential therapeutics". Neuron. July 2025. doi:10.1016/j.neuron.2025.06.012. PMID 40683247. https://www.cell.com/cms/10.1016/j.neuron.2025.06.012/attachment/7d8365fe-51f3-4a28-bf40-9999bec837f6/mmc11.pdf. 
  3. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 




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