Chemistry:CMX521
From HandWiki
CMX521 is an antiviral drug discovered by Chimerix, which was developed for the treatment of norovirus, though it also shows efficacy against related viral diarrheas such as rotavirus and some sapoviruses, astroviruses and adenoviruses. It is a nucleoside analogue which acts as an inhibitor of viral RNA-dependant RNA polymerase.[1][2][3]
See also
References
- ↑ "Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy". Viruses 11 (2): 173. February 2019. doi:10.3390/v11020173. PMID 30791582.
- ↑ "Norovirus antivirals: Where are we now?". Medicinal Research Reviews 39 (3): 860–886. May 2019. doi:10.1002/med.21545. PMID 30584800.
- ↑ "Discovery of Potential Inhibitors for RNA-Dependent RNA Polymerase of Norovirus: Virtual Screening, and Molecular Dynamics". International Journal of Molecular Sciences 22 (1): 171. December 2020. doi:10.3390/ijms22010171. PMID 33375298.
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