Chemistry:Mericitabine

Short description: Chemical compound

Mericitabine

Clinical data
Trade names	Mericitabine
Legal status
Legal status	US: Investigational New Drug
Identifiers
IUPAC name [(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4-fluoro-4-methyl-3-(2-methylpropanoyloxy)oxolan-2-yl]methyl 2-methylpropanoate
CAS Number	940908-79-2 Y
PubChem CID	16122663
ChemSpider	17279576
UNII	TA63JX8X52
KEGG	D10477
Chemical and physical data
Formula	C18H26FN3O6
Molar mass	399.419 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)C(=O)OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=NC2=O)N)(C)F)OC(=O)C(C)C
InChI InChI=1S/C18H26FN3O6/c1-9(2)14(23)26-8-11-13(28-15(24)10(3)4)18(5,19)16(27-11)22-7-6-12(20)21-17(22)25/h6-7,9-11,13,16H,8H2,1-5H3,(H2,20,21,25)/t11-,13-,16-,18-/m1/s1 Key:MLESJYFEMSJZLZ-MAAOGQSESA-N

Mericitabine (RG-7128) is an antiviral drug, a deoxycytidine analog (a type of nucleoside analog). It was developed as a treatment for hepatitis C, acting as a NS5B RNA polymerase inhibitor, but while it showed a good safety profile in clinical trials, it was not sufficiently effective to be used as a stand-alone agent. However mericitabine has been shown to boost the efficacy of other antiviral drugs when used alongside them, and as most modern treatment regimens for hepatitis C use a combination therapy of several antiviral drugs, clinical trials have continued to see if it can form a part of a clinically useful drug treatment program.

See also

• BCX4430
• MK-608
• NITD008
• Valopicitabine