Chemistry:Isobucaine
From HandWiki
Short description: Chemical compound
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| Formula | C15H23NO2 |
| Molar mass | 249.354 g·mol−1 |
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Isobucaine is a local anesthetic.[1]
Synthesis
Synthesis:[2]
The reductive amination between aminomethyl propanol (1) and isobutanal [78-84-2] (2) afforded N-Isobutyl-1,1-dimethyl-2-hydroxyethanamine, CID:18315986 (3). Acylation of the amine with benzoyl chloride [98-88-4] hypothetically goes initially to the amide (4'). The acid catalysis used in the reaction leads to an N to O acyl migration to afford isobucaine (5).
See also
- List of local anesthetics
References
- ↑ Accepted Dental Remedies (26th ed.). Chicago: American Dental Association. 1961. p. 30.
- ↑ "Esters of β-Alkylaminoethanols.". Journal of the American Chemical Society 67 (6): 933–939. June 1945. doi:10.1021/ja01222a017.
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