Chemistry:Cinchocaine
From HandWiki
Short description: Local anaesthetic drug
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | topical, intravenous (for animal euthanasia) |
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| Formula | C20H29N3O2 |
| Molar mass | 343.471 g·mol−1 |
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Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia.[1][2] It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.
Medical use
Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl.[3] It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.
Physical properties
Cinchocaine is relatively insoluble in alkaline aqueous solutions.
See also
- Dibucaine number
References
- ↑ Martindale, The Extra Pharmacopoeia, 30th ed, p1006
- ↑ "Dibucaine". MeSH Browser. U.S. National Library of Medicine. https://meshb.nlm.nih.gov/record/ui?ui=D003992.
- ↑ "Proctosedyl ointment/suppositories (cinchocaine, hydrocortisone)". Netdoctor. 29 November 2020. https://www.netdoctor.co.uk/medicines/digestion/a7401/proctosedyl-ointment-suppositories-cinchocaine-hydrocortisone/.
Further reading
- "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry". Farmaco 60 (5): 419–424. May 2005. doi:10.1016/j.farmac.2005.03.001. PMID 15910814.
- "Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi". Parasitology Research 99 (4): 317–320. September 2006. doi:10.1007/s00436-006-0192-1. PMID 16612626.
- "Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles". Acta Poloniae Pharmaceutica 62 (5): 369–379. 2005. PMID 16459486.
- "Simultaneous Determination of the Ionization Constant and the Solubility of Sparingly Soluble Drug Substances. A Physical Chemistry Experiment.". Journal of Chemical Education 78 (6): 786–788. 2001. doi:10.1021/ed078p786. Bibcode: 2001JChEd..78..786A.
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