Chemistry:Kolaflavanone
Kolaflavanone is a biflavonoid isolated from the nuts of Garcinia kola. It has been reported to exhibit antioxidant, neuroprotective, antidiabetic, and reproductive protective effects in experimental models.
It shows antioxidant activity, including protection against gamma-radiation in animal models. Studies in Drosophila melanogaster suggest potential anti-Parkinson effects as well as increased longevity.[1]
Kolaflavanone (as part of the biflavonoid fraction kolaviron) has also been investigated for protective effects against reproductive toxicity. Findings from animal studies suggest amelioration of chemically or radiation-induced reproductive damage, although vitamin E has shown similar protective effects.[2][3][4] In vitro studies indicate that kolaflavanone may protect neuronal cell lines from toxic insults induced by the herbicide atrazine, a known endocrine-disrupting chemical.[5][6] Kolaflavanone has further been reported to exert antidiabetic effects in experimental models.[7]
Extraction methods for biflavonoids from Garcinia kola nuts, including kolaflavanone, have been described in patent literature.[8]
References
- ↑ "Garcinia kola seed biflavonoid fraction (Kolaviron), increases longevity and attenuates rotenone-induced toxicity in Drosophila melanogaster". Pesticide Biochemistry and Physiology 145: 39–45. February 2018. doi:10.1016/j.pestbp.2018.01.002. PMID 29482730. Bibcode: 2018PBioP.145...39F.
- ↑ "Kolaviron, a biflavonoid complex from Garcinia kola seeds, ameliorates ethanol-induced reproductive toxicity in male wistar rats". Nigerian Journal of Physiological Sciences 28 (1): 9–15. June 2013. PMID 23955400.
- ↑ "Chemoprotection of ethylene glycol monoethyl ether-induced reproductive toxicity in male rats by kolaviron, isolated biflavonoid from Garcinia kola seed". Human & Experimental Toxicology 31 (5): 506–517. May 2012. doi:10.1177/0960327111424301. PMID 22027498. Bibcode: 2012HETox..31..506A.
- ↑ "Possible ameliorative effects of kolaviron against reproductive toxicity in sub-lethally whole body gamma-irradiated rats". Experimental and Toxicologic Pathology 64 (4): 379–385. May 2012. doi:10.1016/j.etp.2010.10.002. PMID 21036568. Bibcode: 2012EToxP..64..379A.
- ↑ "Biflavanone-kolaviron protects human dopaminergic SH-SY5Y cells against atrazine induced toxic insult". Toxicology in Vitro 25 (4): 848–858. June 2011. doi:10.1016/j.tiv.2011.02.005. PMID 21333729. Bibcode: 2011ToxVi..25..848A.
- ↑ "Kolaviron protects apoptotic cell death in PC12 cells exposed to atrazine". Free Radical Research 45 (9): 1061–1073. September 2011. doi:10.3109/10715762.2011.593177. PMID 21726175.
- ↑ "Antidiabetic effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats". African Health Sciences 12 (4): 498–506. December 2012. doi:10.4314/ahs.v12i4.16. PMID 23515095.
- ↑ J Torcol & D Dessolin, U.S. Patent 3,818,110.
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