Chemistry:List of investigational sexual dysfunction drugs

Short description: none

This is a list of investigational sexual dysfunction drugs, or drugs that are currently under development for clinical treatment of sexual dysfunction but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Atrophic vaginitis

• Estetrol (E4; Donesta) – estrogen receptor agonist (Estetrol - Mithra Pharmaceuticals - AdisInsight)
• Lasofoxifene (CP-336156, CP-336156-CB, Fablyn, Oporia) – selective estrogen receptor modulator (Lasofoxifene - Sermonix Pharmaceuticals - AdisInsight)

Erectile dysfunction

• HCP-1302 – undefined mechanism of action (HCP 1302 - AdisInsight)
• Nitroglycerin gel (Eroxon, Futura, MED-2001–MED-2005) – nitric oxide donor (Nitroglycerin gel - Futura Medical - AdisInsight)
• Tadalafil/tamsulosin (HCP-1303, CKD-397, YBH-1603) (Tadalafil/tamsulosin - Hanmi Pharmaceutical - AdisInsight, Tadalafil/tamsulosin - Ildong Pharmaceutical - AdisInsight, Tadalafil/tamsulosin - Chong Kun Dang - AdisInsight, Tadalafil/tamsulosin - Yungjin Pharmaceutical - AdisInsight)
• TT-701 (LY-2452473) – selective androgen receptor modulator (OPK 88004 - AdisInsight)

Female anorgasmia

• Testosterone low-dose intranasal (MPP-14, TBS-2, Noseafix, Tefina) – androgen receptor agonist (Testosterone intranasal (low-dose) - Acerus Pharmaceuticals - AdisInsight)

Female sexual dysfunction

• BP-101 – undefined mechanism of action (BP 101 - Ovoca Bio - AdisInsight)
• Bupropion/trazodone (S1P-104, S1P-205, Lorexys, Orexa) – norepinephrine reuptake inhibitor, nicotinic acetylcholine receptor antagonist, 5-HT_2A receptor antagonist, α₁-adrenergic receptor antagonist, weak serotonin reuptake inhibitor (Bupropion/trazodone - AdisInsight)
• Buspirone/testosterone (Lybridos) – 5-HT_1A receptor partial agonist and androgen receptor agonist (Buspirone/testosterone - Emotional Brain - AdisInsight)
• Lasofoxifene (CP-336156, CP-336156-CB, Fablyn, Oporia) – selective estrogen receptor modulator (Lasofoxifene - Sermonix Pharmaceuticals - AdisInsight)
• PL-6983 – selective MC₄ receptor agonist (Research programme: sexual dysfunction therapy - Palatin Technologies - AdisInsight)
• Sildenafil/testosterone (Lybrido) – PDE5 inhibitor and androgen receptor agonist (Sildenafil/testosterone - Emotional Brain - AdisInsight)
• TGFK09SD – 5-HT_1A receptor agonist (TGFK 09SD - AdisInsight)

Premature ejaculation

• Clomipramine/sildenafil (CDFR-0812) – serotonin reuptake inhibitor and PDE5 inhibitor (Clomipramine/sildenafil - CTC Bio - AdisInsight)
• DA-8031 – serotonin reuptake inhibitor (DA 8031 - AdisInsight)
• IX-01 – oxytocin receptor antagonist (Cligosiban - Ixchelsis - AdisInsight)
• OnabotulinumtoxinA (botulinum toxin A, Botox) – acetylcholine release inhibitor (Onabotulinum toxin A - AbbVie - AdisInsight)

Unspecified

• Vilazodone (Viibryd, EMD-68843, SB-659746A) – 5-HT_1A receptor partial agonist and serotonin reuptake inhibitor (Vilazodone - AbbVie - AdisInsight)

See also

• List of investigational drugs

External links

• AdisInsight - Springer

{{Navbox

| name = Sexual dysfunction pharmacotherapies
| title = Sexual dysfunction pharmacotherapies
| state = autocollapse
| bodyclass = hlist
| listclass = hlist

| group1 = Dopamine agonists
| list1 =

• Apomorphine
• Cabergoline
• Lisuride
• Pergolide
• Piribedil
• Pramipexole
• Quinagolide
• Ropinirole
• Rotigotine
• Terguride

| group2 = Melanocortin agonists
| list2 =

• Bremelanotide
• Melanotan II
• PL-6983

| group3 = PDE5 inhibitors
| list3 =

• Acetildenafil
• Aildenafil
• Avanafil
• Icariin
• Lodenafil
• Mirodenafil
• Nitrosoprodenafil
• Sildenafil
• Sulfoaildenafil
• Tadalafil
• Udenafil
• Vardenafil

| group4 = Sex steroids
| list4 =

• Androgens (e.g., [[testosterone, methyltestosterone, other anabolic steroids)
• Estrogens (e.g., [[estradiol, ethinylestradiol, conjugated equine estrogens (Premarin))
• Progestogens (e.g., [[progesterone, progestins)
• Mixed (e.g., tibolone)

| group5 = Others
| list5 =

• Afrodor (acecarbromal, quebracho, vitamin E)
• Alkyl nitrites
• Alprostadil
• Amantadine
• Bupropion
• Buspirone
• Cyproheptadine
• Dapoxetine
• Flibanserin
• Mirtazapine
• Moxisylyte
• Oxytocin
• Papaverine
• Phentolamine
• Psychostimulants (e.g., amphetamines, cocaine, methylphenidate)
• Rauwolscine (Rauvolfia)
• Trazodone
• Yohimbine (Yohimbe)

| below =

• See also: Drugs for erectile dysfunction and premature ejaculation

}}