Chemistry:Aildenafil
From HandWiki
Short description: Chemical compound
 | This article is missing information about Chinese approval, Dec 2022. (October 2023) |
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| Other names | Methisosildenafil; Dimethyl sildenafil |
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| Formula | C23H32N6O4S |
| Molar mass | 488.61 g·mol−1 |
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Aildenafil (methisosildenafil) is a synthetic drug that is a structural analog of sildenafil (Viagra).[1] It was first reported in 2003,[2] and it is not approved by any health regulation agency. Like sildenafil, aildenafil is a phosphodiesterase type 5 inhibitor.
Aildenafil has been found as an adulterant in a variety of supplements which are sold as "natural" or "herbal" sexual enhancement products.[3][4][5][6][7] The United States Food and Drug Administration has warned consumers that any sexual enhancement product that claims to work as well as prescription products is likely to contain such a contaminant.[8]
See also
References
- ↑ "Pharmacokinetics and safety of aildenafil tablets in healthy Chinese male subjects after multiple dose administration". Zhongguo Linchuang Yaolixue Zazhi 25 (2): 120–123. 2009.
- ↑ Liu B, "New compounds for treating impotence", WO patent 2003016313, published 2003-02-27
- ↑ "Detection of undeclared erectile dysfunction drugs and analogues in dietary supplements by ion mobility spectrometry". Journal of Pharmaceutical and Biomedical Analysis 49 (3): 601–606. April 2009. doi:10.1016/j.jpba.2008.12.002. PMID 19150190.
- ↑ "Determination of analogs of sildenafil and vardenafil in foods by column liquid chromatography with a photodiode array detector, mass spectrometry, and nuclear magnetic resonance spectrometry". Journal of AOAC International 91 (3): 580–588. 2008. doi:10.1093/jaoac/91.3.580. PMID 18567304.
- ↑ "Use of liquid chromatography-mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement". Journal of Pharmaceutical and Biomedical Analysis 44 (4): 887–893. August 2007. doi:10.1016/j.jpba.2007.04.011. PMID 17532168. https://zenodo.org/record/1259165.
- ↑ "Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplement". Journal of Pharmaceutical and Biomedical Analysis 43 (5): 1615–1621. April 2007. doi:10.1016/j.jpba.2006.11.037. PMID 17207601. https://zenodo.org/record/1259163.
- ↑ Enforcement Report for June 30, 2010, United States Food and Drug Administration
- ↑ Hidden Risks of Erectile Dysfunction "Treatments" Sold Online, United States Food and Drug Administration, February 21, 2009
External links
{{Navbox
| name = Sexual dysfunction pharmacotherapies | title = Sexual dysfunction pharmacotherapies | state = autocollapse | bodyclass = hlist | listclass = hlist
| group1 = Dopamine agonists | list1 =
- Apomorphine
- Cabergoline
- Lisuride
- Pergolide
- Piribedil
- Pramipexole
- Quinagolide
- Ropinirole
- Rotigotine
- Terguride
| group2 = Melanocortin agonists | list2 =
| group3 = PDE5 inhibitors | list3 =
- Acetildenafil
- Aildenafil
- Avanafil
- Icariin
- Lodenafil
- Mirodenafil
- Nitrosoprodenafil
- Sildenafil
- Sulfoaildenafil
- Tadalafil
- Udenafil
- Vardenafil
| group4 = Sex steroids | list4 =
- Androgens (e.g., [[testosterone, methyltestosterone, other anabolic steroids)
- Estrogens (e.g., [[estradiol, ethinylestradiol, conjugated equine estrogens (Premarin))
- Progestogens (e.g., [[progesterone, progestins)
- Mixed (e.g., tibolone)
| group5 = Others | list5 =
- Afrodor (acecarbromal, quebracho, vitamin E)
- Alkyl nitrites
- Alprostadil
- Amantadine
- Bupropion
- Buspirone
- Cyproheptadine
- Dapoxetine
- Flibanserin
- Mirtazapine
- Moxisylyte
- Oxytocin
- Papaverine
- Phentolamine
- Psychostimulants (e.g., amphetamines, cocaine, methylphenidate)
- Rauwolscine (Rauvolfia)
- Trazodone
- Yohimbine (Yohimbe)
| below =
}}
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