Chemistry:TMC-647055
From HandWiki
TMC-647055 is an experimental antiviral drug which was developed as a treatment for hepatitis C, and is in clinical trials as a combination treatment with ribavirin and simeprevir. It acts as a NS5b polymerase inhibitor.[1][2][3]
References
- ↑ "Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055". Bioorganic & Medicinal Chemistry Letters 22 (13): 4437–43. July 2012. doi:10.1016/j.bmcl.2012.04.113. PMID 22633687.
- ↑ "Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase". Journal of Medicinal Chemistry 57 (5): 1880–92. March 2014. doi:10.1021/jm401396p. PMID 24144360.
- ↑ "Efficacy, safety and pharmacokinetics of simeprevir and TMC647055/ritonavir with or without ribavirin and JNJ-56914845 in HCV genotype 1 infection". BMC Gastroenterology 17 (1): 26. February 2017. doi:10.1186/s12876-017-0580-2. PMID 28187751.
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