Medicine:Polio

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Short description: Infectious disease caused by poliovirus
Polio
Other namesPoliomyelitis, infantile paralysis, Heine–Medin disease
Polio survivor
A man with a wasted right leg due to poliomyelitis
Pronunciation
SpecialtyNeurology, infectious disease
SymptomsFever, sore throat[1]
ComplicationsMuscle weakness resulting in paralysis;[1] Post-polio syndrome[2]
TypesWild PV types 1,2 & 3; vaccine-derived PV[1]
CausesPoliovirus spread by fecal–oral route[1]
Risk factorsPoor hygiene
Diagnostic methodFinding the virus in the feces or antibodies in the blood[1]
PreventionPolio vaccine[3]
TreatmentNo treatment other than supportive care[3]
Frequency30 (wild) + 856 (vaccine-derived) in 2022[4]

Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus.[1] Approximately 75% of cases are asymptomatic;[5] mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia.[1][3] These symptoms usually pass within one or two weeks.[1] A less common symptom is permanent paralysis, and possible death in extreme cases.[1] Years after recovery, post-polio syndrome may occur, with a slow development of muscle weakness similar to that which the person had during the initial infection.[2]

Polio occurs naturally only in humans.[1] It is highly infectious, and is spread from person to person either through fecal–oral transmission[1][6] (e.g. poor hygiene, or by ingestion of food or water contaminated by human feces), or via the oral–oral route.[1] Those who are infected may spread the disease for up to six weeks even if no symptoms are present.[1] The disease may be diagnosed by finding the virus in the feces or detecting antibodies against it in the blood.[1]

Poliomyelitis has existed for thousands of years, with depictions of the disease in ancient art.[1] The disease was first recognized as a distinct condition by the English physician Michael Underwood in 1789,[1][7] and the virus that causes it was first identified in 1909 by the Austrian immunologist Karl Landsteiner.[8][9] Major outbreaks started to occur in the late 19th century in Europe and the United States ,[1] and in the 20th century, it became one of the most worrying childhood diseases.[10] Following the introduction of polio vaccines in the 1950s polio incidence declined rapidly.[1]

Once infected, there is no specific treatment.[3] The disease can be prevented by the polio vaccine, with multiple doses required for lifelong protection.[3] There are two broad types of polio vaccine; an injected vaccine using inactivated poliovirus and an oral vaccine containing attenuated (weakened) live virus.[1] Through the use of both types of vaccine, incidence of wild polio has decreased from an estimated 350,000 cases in 1988[3] to 30 confirmed cases in 2022, confined to just three countries.[11] There are rare incidents of disease transmission and/or of paralytic polio associated with the attenuated oral vaccine and for this reason the injected vaccine is preferred.[12]

Signs and symptoms

Outcomes of poliovirus infection in children
Outcome Proportion of cases[1]
No symptoms 72%
Minor illness 24%
Nonparalytic aseptic
meningitis 		1–5%
Paralytic poliomyelitis 0.1–0.5%
— Spinal polio 79% of paralytic cases
— Bulbospinal polio 19% of paralytic cases
— Bulbar polio 2% of paralytic cases

The term "poliomyelitis" is used to identify the disease caused by any of the three serotypes of poliovirus. Two basic patterns of polio infection are described: a minor illness which does not involve the central nervous system (CNS), sometimes called abortive poliomyelitis, and a major illness involving the CNS, which may be paralytic or nonparalytic.[13] Adults are more likely to develop symptoms, including severe symptoms, than children.[1]

In most people with a normal immune system, a poliovirus infection is asymptomatic. In about 25% of cases, the infection produces minor symptoms which may include sore throat and low fever.[3][5] These symptoms are temporary and full recovery occurs within one or two weeks.[1][3]

In about 1 percent of infections the virus can migrate from the gastrointestinal tract into the central nervous system (CNS).[1] Most patients with CNS involvement develop nonparalytic aseptic meningitis, with symptoms of headache, neck, back, abdominal and extremity pain, fever, vomiting, stomach pain, lethargy, and irritability.[14][15][16] About one to five in 1000 cases progress to paralytic disease, in which the muscles become weak, floppy and poorly controlled, and, finally, completely paralyzed; this condition is known as acute flaccid paralysis.[17] The weakness most often involves the legs, but may less commonly involve the muscles of the head, neck, and diaphragm.[1] Depending on the site of paralysis, paralytic poliomyelitis is classified as spinal, bulbar, or bulbospinal. In those who develop paralysis, between 2 and 10 percent die as the paralysis affects the breathing muscles.[3]

Encephalitis, an infection of the brain tissue itself, can occur in rare cases, and is usually restricted to infants. It is characterized by confusion, changes in mental status, headaches, fever, and, less commonly, seizures and spastic paralysis.[18]

Cause

Main page: Biology:Poliovirus
A TEM micrograph of poliovirus

Poliomyelitis does not affect any species other than humans.[19] The disease is caused by infection with a member of the genus Enterovirus known as poliovirus (PV). This group of RNA viruses colonize the gastrointestinal tract[20] – specifically the oropharynx and the intestine. Its structure is quite simple, composed of a single (+) sense RNA genome enclosed in a protein shell called a capsid.[19] In addition to protecting the virus' genetic material, the capsid proteins enable poliovirus to infect certain types of cells. Three serotypes of poliovirus have been identified – wild poliovirus type 1 (WPV1), type 2 (WPV2), and type 3 (WPV3) – each with a slightly different capsid protein.[21] All three are extremely virulent and produce the same disease symptoms.[19] PV1 is the most commonly encountered form, and the one most closely associated with paralysis.[22] WPV2 was certified as eradicated in 2015 and WPV3 certified as eradicated in 2019.[23]

The incubation period (from exposure to the first signs and symptoms) ranges from three to six days for nonparalytic polio. If the disease progresses to cause paralysis, this occurs within 7 to 21 days.[1]

Individuals who are exposed to the virus, either through infection or by immunization via polio vaccine, develop immunity. In immune individuals, IgA antibodies against poliovirus are present in the tonsils and gastrointestinal tract and able to block virus replication; IgG and IgM antibodies against PV can prevent the spread of the virus to motor neurons of the central nervous system.[24] Infection or vaccination with one serotype of poliovirus does not provide immunity against the other serotypes, and full immunity requires exposure to each serotype.[24]

A rare condition with a similar presentation, nonpoliovirus poliomyelitis, may result from infections with enteroviruses other than poliovirus.[25]

The oral polio vaccine contains weakened viruses that can replicate. On rare occasions, these may be transmitted from the vaccinated person to other people, who may display symptoms of polio. In communities with good vaccine coverage transmission is limited, and the virus dies out. In communities with low vaccine coverage, this weakened virus may continue to circulate.[26] Polio arising from this cause is referred to as circulating vaccine-derived polio (cVDPV) in order to distinguish it from the natural or "wild" poliovirus (WPV).[27]

Transmission

Poliomyelitis is highly contagious. The disease is transmitted primarily via the fecal–oral route, by ingesting contaminated food or water. It is occasionally transmitted via the oral–oral route.[1] It is seasonal in temperate climates, with peak transmission occurring in summer and autumn. These seasonal differences are far less pronounced in tropical areas.[24] Polio is most infectious between 7 and 10 days before and after the appearance of symptoms, but transmission is possible as long as the virus remains in the saliva or feces. Virus particles can be excreted in the feces for up to six weeks.[5]

Factors that increase the risk of polio infection include pregnancy,[28] the very old and the very young, immune deficiency,[29] and malnutrition.[30] Although the virus can cross the maternal-fetal barrier during pregnancy, the fetus does not appear to be affected by either maternal infection or polio vaccination.[31] Maternal antibodies also cross the placenta, providing passive immunity that protects the infant from polio infection during the first few months of life.[32]

Pathophysiology

A photomicrograph of the lumbar spinal cord depicting an infarct due to Polio Type III surrounding the anterior spinal artery

Poliovirus enters the body through the mouth, infecting the first cells with which it comes in contact – the pharynx and intestinal mucosa. It gains entry by binding to an immunoglobulin-like receptor, known as the poliovirus receptor or CD155, on the cell membrane.[33] The virus then hijacks the host cell's own machinery, and begins to replicate. Poliovirus divides within gastrointestinal cells for about a week, from where it spreads to the tonsils (specifically the follicular dendritic cells residing within the tonsilar germinal centers), the intestinal lymphoid tissue including the M cells of Peyer's patches, and the deep cervical and mesenteric lymph nodes, where it multiplies abundantly. The virus is subsequently absorbed into the bloodstream.[34]

Known as viremia, the presence of a virus in the bloodstream enables it to be widely distributed throughout the body. Poliovirus can survive and multiply within the blood and lymphatics for long periods of time, sometimes as long as 17 weeks.[35] In a small percentage of cases, it can spread and replicate in other sites, such as brown fat, the reticuloendothelial tissues, and muscle.[36] This sustained replication causes a major viremia, and leads to the development of minor influenza-like symptoms. Rarely, this may progress and the virus may invade the central nervous system, provoking a local inflammatory response. In most cases, this causes a self-limiting inflammation of the meninges, the layers of tissue surrounding the brain, which is known as nonparalytic aseptic meningitis.[14] Penetration of the CNS provides no known benefit to the virus, and is quite possibly an incidental deviation of a normal gastrointestinal infection.[37] The mechanisms by which poliovirus spreads to the CNS are poorly understood, but it appears to be primarily a chance event – largely independent of the age, gender, or socioeconomic position of the individual.[37]

Paralytic polio

Denervation of skeletal muscle tissue secondary to poliovirus infection can lead to paralysis.

In around one percent of infections, poliovirus spreads along certain nerve fiber pathways, preferentially replicating in and destroying motor neurons within the spinal cord, brain stem, or motor cortex. This leads to the development of paralytic poliomyelitis, the various forms of which (spinal, bulbar, and bulbospinal) vary only with the amount of neuronal damage and inflammation that occurs, and the region of the CNS affected.

The destruction of neuronal cells produces lesions within the spinal ganglia; these may also occur in the reticular formation, vestibular nuclei, cerebellar vermis, and deep cerebellar nuclei.[37] Inflammation associated with nerve cell destruction often alters the color and appearance of the gray matter in the spinal column, causing it to appear reddish and swollen.[14] Other destructive changes associated with paralytic disease occur in the forebrain region, specifically the hypothalamus and thalamus.[37] The molecular mechanisms by which poliovirus causes paralytic disease are poorly understood.

Early symptoms of paralytic polio include high fever, headache, stiffness in the back and neck, asymmetrical weakness of various muscles, sensitivity to touch, difficulty swallowing, muscle pain, loss of superficial and deep reflexes, paresthesia (pins and needles), irritability, constipation, or difficulty urinating. Paralysis generally develops one to ten days after early symptoms begin, progresses for two to three days, and is usually complete by the time the fever breaks.[38]

The likelihood of developing paralytic polio increases with age, as does the extent of paralysis. In children, nonparalytic meningitis is the most likely consequence of CNS involvement, and paralysis occurs in only one in 1000 cases. In adults, paralysis occurs in one in 75 cases.[39] In children under five years of age, paralysis of one leg is most common; in adults, extensive paralysis of the chest and abdomen also affecting all four limbs – quadriplegia – is more likely.[40] Paralysis rates also vary depending on the serotype of the infecting poliovirus; the highest rates of paralysis (one in 200) are associated with poliovirus type 1, the lowest rates (one in 2,000) are associated with type 2.[41]

Spinal polio

The location of motor neurons in the anterior horn cells of the spinal column

Spinal polio, the most common form of paralytic poliomyelitis, results from viral invasion of the motor neurons of the anterior horn cells, or the ventral (front) grey matter section in the spinal column, which are responsible for movement of the muscles, including those of the trunk, limbs, and the intercostal muscles.[17] Virus invasion causes inflammation of the nerve cells, leading to damage or destruction of motor neuron ganglia. When spinal neurons die, Wallerian degeneration takes place, leading to weakness of those muscles formerly innervated by the now-dead neurons.[42] With the destruction of nerve cells, the muscles no longer receive signals from the brain or spinal cord; without nerve stimulation, the muscles atrophy, becoming weak, floppy and poorly controlled, and finally completely paralyzed.[17] Maximum paralysis progresses rapidly (two to four days), and usually involves fever and muscle pain. Deep tendon reflexes are also affected, and are typically absent or diminished; sensation (the ability to feel) in the paralyzed limbs, however, is not affected.[43]

The extent of spinal paralysis depends on the region of the cord affected, which may be cervical, thoracic, or lumbar.[44] The virus may affect muscles on both sides of the body, but more often the paralysis is asymmetrical.[34] Any limb or combination of limbs may be affected – one leg, one arm, or both legs and both arms. Paralysis is often more severe proximally (where the limb joins the body) than distally (the fingertips and toes).[34]

Bulbar polio

The location and anatomy of the bulbar region (in orange)

Making up about two percent of cases of paralytic polio, bulbar polio occurs when poliovirus invades and destroys nerves within the bulbar region of the brain stem.[1] The bulbar region is a white matter pathway that connects the cerebral cortex to the brain stem. The destruction of these nerves weakens the muscles supplied by the cranial nerves, producing symptoms of encephalitis, and causes difficulty breathing, speaking and swallowing.[16] Critical nerves affected are the glossopharyngeal nerve (which partially controls swallowing and functions in the throat, tongue movement, and taste), the vagus nerve (which sends signals to the heart, intestines, and lungs), and the accessory nerve (which controls upper neck movement). Due to the effect on swallowing, secretions of mucus may build up in the airway, causing suffocation.[38] Other signs and symptoms include facial weakness (caused by destruction of the trigeminal nerve and facial nerve, which innervate the cheeks, tear ducts, gums, and muscles of the face, among other structures), double vision, difficulty in chewing, and abnormal respiratory rate, depth, and rhythm (which may lead to respiratory arrest). Pulmonary edema and shock are also possible and may be fatal.[44]

Bulbospinal polio

Approximately 19 percent of all paralytic polio cases have both bulbar and spinal symptoms; this subtype is called respiratory or bulbospinal polio.[1] Here, the virus affects the upper part of the cervical spinal cord (cervical vertebrae C3 through C5), and paralysis of the diaphragm occurs. The critical nerves affected are the phrenic nerve (which drives the diaphragm to inflate the lungs) and those that drive the muscles needed for swallowing. By destroying these nerves, this form of polio affects breathing, making it difficult or impossible for the patient to breathe without the support of a ventilator. It can lead to paralysis of the arms and legs and may also affect swallowing and heart functions.[45]

Diagnosis

Paralytic poliomyelitis may be clinically suspected in individuals experiencing acute onset of flaccid paralysis in one or more limbs with decreased or absent tendon reflexes in the affected limbs that cannot be attributed to another apparent cause, and without sensory or cognitive loss.[46]

A laboratory diagnosis is usually made based on the recovery of poliovirus from a stool sample or a swab of the pharynx. Rarely, it may be possible to identify poliovirus in the blood or in the cerebrospinal fluid. Poliovirus samples are further analysed using reverse transcription polymerase chain reaction (RT-PCR) or genomic sequencing to determine the serotype (i.e., 1, 2, or 3), and whether the virus is a wild or vaccine-derived strain.[1]

Prevention

Passive immunization

In 1950, William Hammon at the University of Pittsburgh purified the gamma globulin component of the blood plasma of polio survivors.[47] Hammon proposed the gamma globulin, which contained antibodies to poliovirus, could be used to halt poliovirus infection, prevent disease, and reduce the severity of disease in other patients who had contracted polio. The results of a large clinical trial were promising; the gamma globulin was shown to be about 80 percent effective in preventing the development of paralytic poliomyelitis.[48] It was also shown to reduce the severity of the disease in patients who developed polio.[47] Due to the limited supply of blood plasma gamma globulin was later deemed impractical for widespread use and the medical community focused on the development of a polio vaccine.[49]

Vaccine

Main page: Engineering:Polio vaccine
A child receiving an oral polio vaccine

Two types of vaccine are used throughout the world to combat polio. Both types induce immunity to polio and are effective in protecting individuals from disease.

The first candidate polio vaccine, based on one serotype of a live but attenuated (weakened) virus, was developed by the virologist Hilary Koprowski. Koprowski's prototype vaccine was given to an eight-year-old boy on 27 February 1950.[50] Koprowski continued to work on the vaccine throughout the 1950s, leading to large-scale trials in the then Belgian Congo and the vaccination of seven million children in Poland against serotypes PV1 and PV3 between 1958 and 1960.[51]

The second polio virus vaccine was developed in 1952 by Jonas Salk at the University of Pittsburgh, and announced to the world on 12 April 1955.[52][53] The Salk vaccine, or inactivated poliovirus vaccine (IPV), is based on poliovirus grown in a type of monkey kidney tissue culture (vero cell line), which is chemically inactivated with formalin.[24] After two doses of inactivated poliovirus vaccine (given by injection), 90 percent or more of individuals develop protective antibody to all three serotypes of poliovirus, and at least 99 percent are immune to poliovirus following three doses.[1]

Subsequently, Albert Sabin developed another live, oral polio vaccine (OPV). It was produced by the repeated passage of the virus through nonhuman cells at subphysiological temperatures.[54] The attenuated poliovirus in the Sabin vaccine replicates very efficiently in the gut, the primary site of wild poliovirus infection and replication, but the vaccine strain is unable to replicate efficiently within nervous system tissue.[55] A single dose of Sabin's oral polio vaccine produces immunity to all three poliovirus serotypes in about 50 percent of recipients. Three doses of live-attenuated oral vaccine produce protective antibody to all three poliovirus types in more than 95 percent of recipients.[1] Human trials of Sabin's vaccine began in 1957,[56] and in 1958, it was selected, in competition with the live vaccines of Koprowski and other researchers, by the US National Institutes of Health.[51] Licensed in 1962,[56] it rapidly became the only polio vaccine used worldwide.[51]

OPV efficiently blocks person-to-person transmission of wild poliovirus by oral–oral and fecal–oral routes, thereby protecting both individual vaccine recipients and the wider community (herd immunity).[57] IPV confers good immunity but is less effective at preventing spread of wild poliovirus by the fecal–oral route.[58]

Wild polio vs cVDVP cases (2000–2019)

Because the oral polio vaccine is inexpensive, easy to administer, and produces excellent immunity in the intestine (which helps prevent infection with wild virus in areas where it is endemic), it has been the vaccine of choice for controlling poliomyelitis in many countries.[59] On very rare occasions (about one case per 750,000 vaccine recipients), the attenuated virus in the oral polio vaccine reverts into a form that can paralyze.[60] In 2017, cases caused by vaccine-derived poliovirus (cVDPV) outnumbered wild poliovirus cases for the first time, due to wild polio cases hitting record lows.[61] Most industrialized countries have switched to inactivated polio vaccine, which cannot revert, either as the sole vaccine against poliomyelitis or in combination with oral polio vaccine.[62]

Treatment

There is no cure for polio, but there are treatments. The focus of modern treatment has been on providing relief of symptoms, speeding recovery and preventing complications. Supportive measures include antibiotics to prevent infections in weakened muscles, analgesics for pain, moderate exercise and a nutritious diet.[63] Treatment of polio often requires long-term rehabilitation, including occupational therapy, physical therapy, braces, corrective shoes and, in some cases, orthopedic surgery.[44]

Portable ventilators may be required to support breathing. Historically, a noninvasive, negative-pressure ventilator, more commonly called an iron lung, was used to artificially maintain respiration during an acute polio infection until a person could breathe independently (generally about one to two weeks). Today, many polio survivors with permanent respiratory paralysis use modern jacket-type negative-pressure ventilators worn over the chest and abdomen.[64]

Other historical treatments for polio include hydrotherapy, electrotherapy, massage and passive motion exercises, and surgical treatments, such as tendon lengthening and nerve grafting.[17]

Sister Elizabeth Kenny's Kenny regimen is now the hallmark for the treatment of paralytic polio.[65]

Prognosis

A girl with genu recurvatum of her right leg due to polio

Patients with abortive polio infections recover completely. In those who develop only aseptic meningitis, the symptoms can be expected to persist for two to ten days, followed by complete recovery.[66] In cases of spinal polio, if the affected nerve cells are completely destroyed, paralysis will be permanent; cells that are not destroyed, but lose function temporarily, may recover within four to six weeks after onset.[66] Half the patients with spinal polio recover fully; one-quarter recover with mild disability, and the remaining quarter are left with severe disability.[67] The degree of both acute paralysis and residual paralysis is likely to be proportional to the degree of viremia, and inversely proportional to the degree of immunity.[37] Spinal polio is rarely fatal.[38]

Without respiratory support, consequences of poliomyelitis with respiratory involvement include suffocation or pneumonia from aspiration of secretions.[64] Overall, 5 to 10 percent of patients with paralytic polio die due to the paralysis of muscles used for breathing. The case fatality rate (CFR) varies by age: 2 to 5 percent of children and up to 15 to 30 percent of adults die.[1] Bulbar polio often causes death if respiratory support is not provided;[45] with support, its CFR ranges from 25 to 75 percent, depending on the age of the patient.[1][68] When intermittent positive pressure ventilation is available, the fatalities can be reduced to 15 percent.[69]

Recovery

Many cases of poliomyelitis result in only temporary paralysis.[17] Generally in these cases, nerve impulses return to the paralyzed muscle within a month, and recovery is complete in six to eight months.[66] The neurophysiological processes involved in recovery following acute paralytic poliomyelitis are quite effective; muscles are able to retain normal strength even if half the original motor neurons have been lost.[70] Paralysis remaining after one year is likely to be permanent, although some recovery of muscle strength is possible up to 18 months after infection.[66]

One mechanism involved in recovery is nerve terminal sprouting, in which remaining brainstem and spinal cord motor neurons develop new branches, or axonal sprouts.[71] These sprouts can reinnervate orphaned muscle fibers that have been denervated by acute polio infection,[72] restoring the fibers' capacity to contract and improving strength.[73] Terminal sprouting may generate a few significantly enlarged motor neurons doing work previously performed by as many as four or five units:[39] a single motor neuron that once controlled 200 muscle cells might control 800 to 1000 cells. Other mechanisms that occur during the rehabilitation phase, and contribute to muscle strength restoration, include myofiber hypertrophy – enlargement of muscle fibers through exercise and activity – and transformation of type II muscle fibers to type I muscle fibers.[72][74]

In addition to these physiological processes, the body can compensate for residual paralysis in other ways. Weaker muscles can be used at a higher than usual intensity relative to the muscle's maximal capacity, little-used muscles can be developed, and ligaments can enable stability and mobility.[74]

Complications

Residual complications of paralytic polio often occur following the initial recovery process.[16] Muscle paresis and paralysis can sometimes result in skeletal deformities, tightening of the joints, and movement disability. Once the muscles in the limb become flaccid, they may interfere with the function of other muscles. A typical manifestation of this problem is equinus foot (similar to club foot). This deformity develops when the muscles that pull the toes downward are working, but those that pull it upward are not, and the foot naturally tends to drop toward the ground. If the problem is left untreated, the Achilles tendons at the back of the foot retract and the foot cannot take on a normal position. People with polio that develop equinus foot cannot walk properly because they cannot put their heels on the ground. A similar situation can develop if the arms become paralyzed.[75]

In some cases the growth of an affected leg is slowed by polio, while the other leg continues to grow normally. The result is that one leg is shorter than the other and the person limps and leans to one side, in turn leading to deformities of the spine (such as scoliosis).[75] Osteoporosis and increased likelihood of bone fractures may occur. An intervention to prevent or lessen length disparity can be to perform an epiphysiodesis on the distal femoral and proximal tibial/fibular condyles, so that limb's growth is artificially stunted, and by the time of epiphyseal (growth) plate closure, the legs are more equal in length. Alternatively, a person can be fitted with custom-made footwear which corrects the difference in leg lengths. Other surgery to re-balance muscular agonist/antagonist imbalances may also be helpful. Extended use of braces or wheelchairs may cause compression neuropathy, as well as a loss of proper function of the veins in the legs, due to pooling of blood in paralyzed lower limbs.[45][76] Complications from prolonged immobility involving the lungs, kidneys and heart include pulmonary edema, aspiration pneumonia, urinary tract infections, kidney stones, paralytic ileus, myocarditis and cor pulmonale.[45][76]

Post-polio syndrome

Main page: Medicine:Post-polio syndrome

Between 25 percent and 50 percent of individuals who have recovered from paralytic polio in childhood can develop additional symptoms decades after recovering from the acute infection,[77] notably new muscle weakness and extreme fatigue. This condition is known as post-polio syndrome (PPS) or post-polio sequelae.[73] The symptoms of PPS are thought to involve a failure of the oversized motor units created during the recovery phase of the paralytic disease.[78][79] Contributing factors that increase the risk of PPS include aging with loss of neuron units, the presence of a permanent residual impairment after recovery from the acute illness, and both overuse and disuse of neurons. PPS is a slow, progressive disease, and there is no specific treatment for it.[73] Post-polio syndrome is not an infectious process, and persons experiencing the syndrome do not shed poliovirus.[1]

Orthotics

Orthosis with stance phase control knee joint

Paralysis, length differences and deformations of the lower extremities can lead to a hindrance when walking with compensation mechanisms that lead to a severe impairment of the gait pattern. In order to be able to stand and walk safely and to improve the gait pattern, orthotics can be included in the therapy concept. Today, modern materials and functional elements enable the orthosis to be specifically adapted to the requirements resulting from the patient's gait. Mechanical stance phase control knee joints may secure the knee joint in the early stance phases and release again for knee flexion when the swing phase is initiated. With the help of an orthotic treatment with a stance phase control knee joint, a natural gait pattern can be achieved despite mechanical protection against unwanted knee flexion. In these cases, locked knee joints are often used, which have a good safety function, but do not allow knee flexion when walking during swing phase. With such joints, the knee joint remains mechanically blocked during the swing phase. Patients with locked knee joints must swing the leg forward with the knee extended even during the swing phase. This only works if the patient develops compensatory mechanisms, e.g. by raising the body's center of gravity in the swing phase (Duchenne limping) or by swinging the orthotic leg to the side (circumduction).[80][81][82]

Epidemiology

Reported polio cases in 2019[83][84]
Polio worldwide 2019.svg
Country Wild cases Circulating vaccine-derived cases (cVDPV) Transmission status Type
 Pakistan 147 22 endemic WPV1
cVDPV2
 Afghanistan 29 0 endemic WPV1
 Angola 0 129 cVDPV only cVDPV2
Template:Country data DRC 0 86 cVDPV only cVDPV2
Template:Country data CAR 0 19 cVDPV only cVDPV2
 Ghana 0 18 cVDPV only cVDPV2
 Nigeria 0 18 cVDPV only cVDPV2
 Philippines 0 15 cVDPV only cVDPV1
cVDPV2
 Ethiopia 0 12 cVDPV only cVDPV2
 Chad 0 9 cVDPV only cVDPV2
 Benin 0 8 cVDPV only cVDPV2
 Togo 0 8 cVDPV only cVDPV2
 Myanmar 0 6 cVDPV only cVDPV1
 Somalia 0 3 cVDPV only cVDPV2
 Malaysia 0 3 cVDPV only cVDPV1
 Zambia 0 2 cVDPV only cVDPV2
 Burkina Faso 0 1 cVDPV only cVDPV2
 China 0 1 cVDPV only cVDPV2
 Niger 0 1 cVDPV only cVDPV2
 Yemen 0 3 cVDPV only cVDPV1
Total 175 365
The decade of the last recorded case of paralytic polio. Since the creation of this image, Nigeria has been certified free of wild polio as of August 2020 and one case was recorded in the US state of New York in July 2022.[85]

Eradication

Following the widespread use of poliovirus vaccine in the mid-1950s, new cases of poliomyelitis declined dramatically in many industrialized countries. A global effort to eradicate polio – the Global Polio Eradication Initiative – began in 1988, led by the World Health Organization, UNICEF, and The Rotary Foundation.[86] Polio is one of only two diseases currently the subject of a global eradication program, the other being Guinea worm disease.[87] So far, the only diseases completely eradicated by humankind are smallpox, declared eradicated in 1980,[88][89] and rinderpest, declared eradicated in 2011.[90] In April 2012, the World Health Assembly declared that the failure to completely eradicate polio would be a programmatic emergency for global public health, and that it "must not happen."[91]

These efforts have hugely reduced the number of cases; from an estimated 350,000 cases in 1988 to a low of 483 cases in 2001, after which it remained at a level of about 1,000–2000 cases per year for a number of years.[92][93]

By 2015, polio was believed to remain naturally spreading in only two countries, Pakistan and Afghanistan,[94][95][96][97] although it continued to cause outbreaks in other nearby countries due to hidden or reestablished transmission.[98] Between 2016 and 2020 worldwide cases of wild polio (mostly in these countries) remained below 200 per year, with only 30 confirmed cases in 2022.[11]

Circulating vaccine-derived polioviruses

The oral polio vaccine, while highly effective, has the disadvantage that it contains a live virus which has been attenuated so that it cannot cause severe illness. The vaccine virus is excreted in the stool, and in under-immunized communities it can spread from person to person. This is known as circulating vaccine-derived poliovirus (cVDPV).

With prolonged transmission of this kind, the weakened virus can mutate and revert to a form that causes illness and paralysis. Cases of cVDPV now exceed wild-type cases, making it desirable to discontinue the use of the oral polio vaccine as soon as safely possible and instead use other types of polio vaccines.[12][99]

Afghanistan and Pakistan

The last remaining region with wild polio cases are the South Asian countries Afghanistan and Pakistan .

During 2011, the CIA ran a fake hepatitis vaccination clinic in Abbottabad, Pakistan, in an attempt to locate Osama bin Laden. This destroyed trust in vaccination programs in the region.[100][101] There were attacks and deaths among vaccination workers; 66 vaccinators were killed in 2013 and 2014.[102][103] In Afghanistan, the Taliban banned house-to-house polio vaccination between 2018 and 2021.[104] These factors have set back efforts to eliminate polio by means of vaccination in these countries.[105]

In Afghanistan, 80 cases of polio were reported from 35 districts during 2011. Incidence over the subsequent 10 years has declined to just 4 cases in 2 districts during 2021.[106][107]

In Pakistan, cases dropped by 97 percent from 2014 to 2018;[108] reasons include 440 million dirham support from the United Arab Emirates to vaccinate more than ten million children,[103][109] changes in the military situation, and arrests of some of those who attacked polio workers.[110][111] During 2021 only one case of wild polio was detected in Pakistan.[11]

Americas

The Americas were declared polio-free in 1994.[112] The last known case was a boy in Peru in 1991.[113] The US Centers for Disease Control and Prevention recommends polio vaccination boosters for travelers and those who live in countries where the disease is endemic.[114]

In July 2022, the US state of New York reported a polio case for the first time in almost a decade in the country. Health officials said the person, an unvaccinated young adult who had not recently travelled abroad, first showed symptoms a month earlier and eventually developed paralysis; this was subsequently attributed to a vaccine-derived strain of the virus.[115] In October, the CDC reported detection of vaccine-derived virus in wastewater samples collected from five New York counties.[116][117]

Western Pacific

In 2000, polio was declared to have been officially eliminated in 37 Western Pacific countries, including China and Australia.[118][119]

Despite eradication ten years earlier, an outbreak was confirmed in China in September 2011, involving a strain common in Pakistan.[120]

In September 2019, the Department of Health of the Philippines declared a polio outbreak in the country after a single case in a 3-year-old girl.[121] The outbreak was declared to be ended during June 2021.[122] In December 2019, acute poliomyelitis was confirmed in an infant in Sabah state, Borneo, Malaysia.[123] Subsequently, a further three polio cases were reported, with the last case reported in January 2020. Prior to this, Malaysia had been declared polio-free in 2000. WHO declared an end to the outbreak in September 2021.[124] Both outbreaks were found to be linked instances of vaccine-derived poliomyelitis.[125]

Europe

Europe was declared polio-free in 2002.[126]

Southeast Asia

The last case of polio in the region was in India (part of the WHO's South-East Asia Region) in January 2011.[127] Since January 2011, there have been no reported cases of the wild polio infections in India, and in February 2012 the country was taken off the WHO list of polio endemic countries.[128][129]

On 27 March 2014, the WHO announced the eradication of poliomyelitis in the South-East Asia Region, which includes eleven countries: Bangladesh, Bhutan, North Korea, India , Indonesia, Maldives, Myanmar, Nepal, Sri Lanka, Thailand and Timor-Leste.[94] With the addition of this region, 80 per cent of the world population was considered to be living in polio-free regions.[94]

Middle East

In Syria difficulties in executing immunization programs in the ongoing civil war led to a return of polio, probably in 2012,[130] acknowledged by the WHO in 2013.[131][132] 15 cases were confirmed among children in Syria between October and November 2013 in Deir Ezzor. Later, two more cases, one each in rural Damascus and Aleppo, were identified. It was the first outbreak in Syria since 1999. Doctors and international public health agencies report more than 90 cases of polio in Syria, with fears of contagion in rebel areas from lack of sanitation and safe-water services.[133] A vaccination campaign in Syria operated literally under fire and led to the deaths of several vaccinators,[134] but returned vaccination coverage to pre-war levels.[135]

An outbreak of vaccine-derived polio was confirmed in 2017 in eastern Syria.[136][137] Syria is currently free of polio, but is considered "at risk".[138]

Africa

Polio vaccination in Egypt

In 2003 in northern Nigeria – a country which at that time was considered provisionally polio free – a fatwa was issued declaring that the polio vaccine was designed to render children sterile.[139] Subsequently, polio reappeared in Nigeria and spread from there to several other countries. In 2013, nine health workers administering polio vaccine were targeted and killed by gunmen on motorcycles in Kano, but this was the only attack.[140][141] Local traditional and religious leaders and polio survivors worked to revive the campaign,[142] and Nigeria was removed from the polio-endemic list in September 2015 after more than a year without any cases,[143] only to be restored to the list in 2016 when two cases were detected.[144]

Africa was declared free of wild polio in August 2020, although cases of circulating vaccine-derived poliovirus type 2 continue to appear in several countries.[145]

A single case of wild polio which was detected in Malawi in February 2022, and another in Mozambique in May 2022 were both of a strain imported from Pakistan and do not affect the African region's wild poliovirus-free certification status.[146][147]

History

An Egyptian stele thought to represent a person with polio, 18th Dynasty (1403–1365 BC)

The effects of polio have been known since prehistory; Egyptian paintings and carvings depict otherwise healthy people with withered limbs, and young children walking with canes.[148] The earliest known case of polio is indicated by the remains of a teenage girl discovered in a 4000-year-old burial site in the United Arab Emirates, exhibiting characteristic symptoms of the condition.[149]

The first clinical description was provided by the English physician Michael Underwood in 1789, where he refers to polio as "a debility of the lower extremities".[150] The work of physicians Jakob Heine in 1840 and Karl Oskar Medin in 1890 led to it being known as Heine–Medin disease.[151] The disease was later called infantile paralysis, based on its propensity to affect children.

Before the 20th century, polio infections were rarely seen in infants before six months of age, most cases occurring in children six months to four years of age. Poorer sanitation of the time resulted in constant exposure to the virus, which enhanced a natural immunity within the population. In developed countries during the late 19th and early 20th centuries, improvements were made in community sanitation, including better sewage disposal and clean water supplies. These changes drastically increased the proportion of children and adults at risk of paralytic polio infection, by reducing childhood exposure and immunity to the disease.[152]

Small localized paralytic polio epidemics began to appear in Europe and the United States around 1900.[153] Outbreaks reached pandemic proportions in Europe, North America, Australia, and New Zealand during the first half of the 20th century. By 1950, the peak age incidence of paralytic poliomyelitis in the United States had shifted from infants to children aged five to nine years, when the risk of paralysis is greater; about one-third of the cases were reported in persons over 15 years of age.[154] Accordingly, the rate of paralysis and death due to polio infection also increased during this time.[153] In the United States, the 1952 polio epidemic became the worst outbreak in the nation's history. Of the nearly 58,000 cases reported that year, 3,145 died and 21,269 were left with mild to disabling paralysis.[155] Intensive care medicine has its origin in the fight against polio.[156] Most hospitals in the 1950s had limited access to iron lungs for patients unable to breathe without mechanical assistance. Respiratory centers designed to assist the most severe polio patients, first established in 1952 at the Blegdam Hospital of Copenhagen by Denmark anesthesiologist Bjørn Ibsen, were the precursors of modern intensive care units (ICU). (A year later, Ibsen would establish the world's first dedicated ICU.)[157]

The polio epidemics not only altered the lives of those who survived them, but also brought profound cultural changes, spurring grassroots fund-raising campaigns that would revolutionize medical philanthropy, and giving rise to the modern field of rehabilitation therapy. As one of the largest disabled groups in the world, polio survivors also helped to advance the modern disability rights movement through campaigns for the social and civil rights of the disabled. The World Health Organization estimates that there are 10 to 20 million polio survivors worldwide.[158] In 1977, there were 254,000 persons living in the United States who had been paralyzed by polio.[159] According to doctors and local polio support groups, some 40,000 polio survivors with varying degrees of paralysis were living in Germany, 30,000 in Japan, 24,000 in France, 16,000 in Australia, 12,000 in Canada and 12,000 in the United Kingdom in 2001.[158] Many notable individuals have survived polio and often credit the prolonged immobility and residual paralysis associated with polio as a driving force in their lives and careers.[160]

The disease was very well publicized during the polio epidemics of the 1950s, with extensive media coverage of any scientific advancements that might lead to a cure. Thus, the scientists working on polio became some of the most famous of the century. Fifteen scientists and two laymen who made important contributions to the knowledge and treatment of poliomyelitis are honored by the Polio Hall of Fame, which was dedicated in 1957 at the Roosevelt Warm Springs Institute for Rehabilitation in Warm Springs, Georgia, US. In 2008 four organizations (Rotary International, the World Health Organization, the U.S. Centers for Disease Control and UNICEF) were added to the Hall of Fame.[161][162]

World Polio Day (24 October) was established by Rotary International to commemorate the birth of Jonas Salk, who led the first team to develop a vaccine against poliomyelitis. Use of this inactivated poliovirus vaccine and subsequent widespread use of the oral poliovirus vaccine developed by Albert Sabin led to establishment of the Global Polio Eradication Initiative (GPEI) in 1988. Since then, GPEI has reduced polio worldwide by 99 percent.[163]

Etymology

The term derives from the Ancient Greek poliós (πολιός), meaning "grey", myelós (µυελός "marrow"), referring to the grey matter of the spinal cord, and the suffix -itis, which denotes inflammation,[14] i.e., inflammation of the spinal cord's grey matter, although a severe infection can extend into the brainstem and even higher structures, resulting in polioencephalitis, resulting in inability to breathe, requiring mechanical assistance such as an iron lung.

Research

The Poliovirus Antivirals Initiative was launched in 2007 with the aim of developing antiviral medications for polio, but while several promising candidates were identified, none have progressed beyond Phase II clinical trials.[164][165] Pocapavir (a capsid inhibitor) and V-7404 (a protease inhibitor) may speed up viral clearance and are being studied for this purpose.[166]

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 1.25 1.26 1.27 1.28 1.29 1.30 1.31 1.32 1.33 Estivariz, Concepcion F.; Link-Gelles, Ruth; Shimabukuro, Tom (2021). "Chapter 18: Poliomyelitis". Epidemiology and Prevention of Vaccine-Preventable Diseases (The Pink Book) (14th ed.). Centers for Disease Control and Prevention (CDC, US). https://www.cdc.gov/vaccines/pubs/pinkbook/polio.html. .
  2. ↑ 2.0 2.1 "Post-Polio Syndrome Fact Sheet". NIH. 16 April 2014. http://www.ninds.nih.gov/disorders/post_polio/detail_post_polio.htm. 
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 "Poliomyelitis: Key facts". World Health Organisation. 22 July 2019. https://www.who.int/en/news-room/fact-sheets/detail/poliomyelitis. 
  4. ↑ "This page allows you to request a table with AFP/polio data". https://extranet.who.int/polis/public/CaseCount.aspx. 
  5. ↑ 5.0 5.1 5.2 "Disease factsheet about poliomyelitis". 26 March 2013. https://www.ecdc.europa.eu/en/poliomyelitis/facts. 
  6. ↑ CDC (2022-03-29). "What is Polio?". https://www.cdc.gov/polio/what-is-polio/index.htm. 
  7. ↑ Underwood, Michael (1789). A Treatise on the Diseases of Children. 2. London, England: J. Mathews. pp. 53–57. https://archive.org/details/b28771254_0002/page/52/mode/2up. 
  8. ↑ Polio (1st ed.). Rochester, NY: University of Rochester Press. 1999. p. 11. ISBN 9781580460668. https://books.google.com/books?id=BTQKnkpN6qQC&pg=PA11. 
  9. ↑ Landsteiner, Karl; Popper, Erwin (1909). "Übertragung der Poliomyelitis acuta auf Affen" (in German). Zeitschrift für Immunitätsforschung und experimentelle Therapie [Journal for Research on Immunity and Experimental Therapy] 2 (4): 377–390. https://babel.hathitrust.org/cgi/pt?id=uc1.b3208372&view=1up&seq=389&skin=2021. Retrieved 9 September 2021. 
  10. ↑ Science and practice of pediatric critical care medicine. London: Springer. 2009. pp. 10–11. ISBN 9781848009219. https://books.google.com/books?id=3p7jezlQ0zgC&pg=PA11. 
  11. ↑ 11.0 11.1 11.2 World Health Organization (Jan 3, 2023). "Global Wild Poliovirus 2016 - 2022". https://polioeradication.org/wp-content/uploads/2023/01/weekly-polio-analyses-WPV-20230103.pdf. 
  12. ↑ 12.0 12.1 "Polio Vaccine: Vaccine-Derived Poliovirus | CDC". 2022-05-06. https://www.cdc.gov/vaccines/vpd/polio/hcp/vaccine-derived-poliovirus-faq.html. 
  13. ↑ "Late functional loss in nonparalytic polio". American Journal of Physical Medicine & Rehabilitation 79 (1): 19–23. 2000. doi:10.1097/00002060-200001000-00006. PMID 10678598. 
  14. ↑ 14.0 14.1 14.2 14.3 The Gale Encyclopedia of Neurological Disorders. Detroit: Thomson Gale. 2005. pp. 1859–70. ISBN 978-0-7876-9150-9. https://archive.org/details/isbn_9780787691516. 
  15. ↑ CDC (2022-03-29). "What is Polio?". https://www.cdc.gov/polio/what-is-polio/index.htm. 
  16. ↑ 16.0 16.1 16.2 The late effects of Polio: Information For Health Care Providers.. Commonwealth Department of Community Services and Health. 1992. ISBN 978-1-875412-05-1. http://www.health.qld.gov.au/polio/gp/GP_Manual.pdf. Retrieved 23 August 2008. 
  17. ↑ 17.0 17.1 17.2 17.3 17.4 Manual of infantile paralysis, with modern methods of treatment.. Philadelphia Davis. 1914. pp. 79–101. OCLC 2078290. https://archive.org/details/amanualinfantil00fraugoog. 
  18. ↑ Principles of Critical Care (3rd ed.). McGraw-Hill Professional. 2005. p. 870. ISBN 978-0-07-141640-5. https://archive.org/details/principlescritic00hall_433. 
  19. ↑ 19.0 19.1 19.2 "Enteroviruses". Sherris Medical Microbiology (4th ed.). McGraw Hill. 2004. pp. 535–37. ISBN 978-0-8385-8529-0. https://archive.org/details/sherrismedicalmi00ryan. 
  20. ↑ Cohen JI (2004). "Chapter 175: Enteroviruses and Reoviruses". Harrison's Principles of Internal Medicine (16th ed.). McGraw-Hill Professional. p. 1144. ISBN 978-0-07-140235-4. 
  21. ↑ Krugman's infectious diseases of children. St. Louis: Mosby. 2004. pp. 81–97. ISBN 978-0-323-01756-5. https://archive.org/details/krugmansinfectio00gers_995. 
  22. ↑ "Polio: Will We Soon Vanquish an Old Enemy?". Drug Benefit Trends 11 (6): 41–54. 1999. http://www.medscape.com/viewarticle/416890. Retrieved 23 August 2008.  (Available free on Medscape; registration required.)
  23. ↑ "Two out of three wild poliovirus strains eradicated". https://www.who.int/news-room/feature-stories/detail/two-out-of-three-wild-poliovirus-strains-eradicated. 
  24. ↑ 24.0 24.1 24.2 24.3 "Vaccine-derived polioviruses and the endgame strategy for global polio eradication". Annual Review of Microbiology 59: 587–635. 2005. doi:10.1146/annurev.micro.58.030603.123625. PMID 16153180. https://zenodo.org/record/1235033. Retrieved 30 June 2019. 
  25. ↑ "Nonpoliovirus poliomyelitis simulating Guillain-Barré syndrome". Archives of Neurology 58 (9): 1460–64. September 2001. doi:10.1001/archneur.58.9.1460. PMID 11559319. 
  26. ↑ "What is vaccine-derived polio?". https://www.gavi.org/vaccineswork/what-vaccine-derived-polio. 
  27. ↑ "GPEI-Vaccine-Derived Polioviruses". https://polioeradication.org/polio-today/polio-prevention/the-virus/vaccine-derived-polio-viruses/. 
  28. ↑ "Factors influencing the occurrence of illness during naturally acquired poliomyelitis virus infections". Bacteriological Reviews 24 (4): 341–52. December 1960. doi:10.1128/MMBR.24.4.341-352.1960. PMID 13697553. 
  29. ↑ Polio and the late effects of polio, Department of Health, State Government of Victoria, Australia, https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/polio-and-post-polio-syndrome, retrieved 2023-04-12 
  30. ↑ "Reduced secretory antibody response to live attenuated measles and poliovirus vaccines in malnourished children". British Medical Journal 2 (5971): 583–5. June 1975. doi:10.1136/bmj.2.5971.583. PMID 1131622. 
  31. ↑ Chapter 26:Poliomyelitis. in: Immunisation Against Infectious Disease, 2006. Edinburgh: Stationery Office. 2006. pp. 313–29. ISBN 978-0-11-322528-6. http://www.immunisation.nhs.uk/files/GB_26_polio.pdf. Retrieved 9 March 2007. 
  32. ↑ "Antibodies against vaccine-preventable diseases in pregnant women and their offspring in the eastern part of Germany". Medical Microbiology and Immunology 190 (4): 167–72. March 2002. doi:10.1007/s00430-001-0100-3. PMID 12005329. 
  33. ↑ "Complexes of poliovirus serotypes with their common cellular receptor, CD155". Journal of Virology 77 (8): 4827–35. April 2003. doi:10.1128/JVI.77.8.4827-4835.2003. PMID 12663789. 
  34. ↑ 34.0 34.1 34.2 "Picornaviruses: The Enteroviruses: Polioviruses". Baron's Medical Microbiology (4th ed.). Univ of Texas Medical Branch. 1996. ISBN 978-0-9631172-1-2. https://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.2862. 
  35. ↑ Todar K (2006). "Polio". Ken Todar's Microbial World. University of Wisconsin – Madison. http://textbookofbacteriology.net/themicrobialworld/Polio.html. 
  36. ↑ "Pathogenesis of poliomyelitis; reappraisal in the light of new data". Science 123 (3209): 1151–57. June 1956. doi:10.1126/science.123.3209.1151. PMID 13337331. Bibcode: 1956Sci...123.1151S. 
  37. ↑ 37.0 37.1 37.2 37.3 37.4 "Poliovirus and poliomyelitis: a tale of guts, brains, and an accidental event". Virus Research 111 (2): 175–93. August 2005. doi:10.1016/j.virusres.2005.04.008. PMID 15885840. 
  38. ↑ 38.0 38.1 38.2 Polio. Diseases and People. Berkeley Heights, NJ: Enslow Publishers. 2001. p. 12. ISBN 978-0-7660-1592-0. https://archive.org/details/poliodiseasespeo00alvi/page/12. 
  39. ↑ 39.0 39.1 "Post-polio syndrome: pathophysiology and clinical management". Critical Review in Physical Medicine and Rehabilitation 7 (2): 147–88. 1995. doi:10.1615/CritRevPhysRehabilMed.v7.i2.40. http://www.poliosurvivorsnetwork.org.uk/archive/lincolnshire/library/gawne/ppspandcm.html. Retrieved 30 June 2016.  Reproduced online with permission by Lincolnshire Post-Polio Library; retrieved on 10 November 2007.
  40. ↑ "Occupational therapy and the postpolio syndrome". The American Journal of Occupational Therapy 43 (2): 97–103. February 1989. doi:10.5014/ajot.43.2.97. PMID 2522741. 
  41. ↑ "The epidemiology of poliomyelitis: enigmas surrounding its appearance, epidemicity, and disappearance". American Journal of Epidemiology 110 (6): 672–92. December 1979. doi:10.1093/oxfordjournals.aje.a112848. PMID 400274. 
  42. ↑ "A photomicrograph of the thoracic spinal cord depicting degenerative changes due to Polio Type III.". Centers for Disease Control and Prevention. 18 March 2005. http://phil.cdc.gov/phil/details.asp?pid=2760. 
  43. ↑ "Chapter 12: Poliomyelitis". Centers for Disease Control and Prevention. 13 April 2013. https://www.cdc.gov/vaccines/pubs/surv-manual/chpt12-polio.html. 
  44. ↑ 44.0 44.1 44.2 Professional Guide to Diseases (Professional Guide Series). Hagerstown, MD: Lippincott Williams & Wilkins. 2005. pp. 243–45. ISBN 978-1-58255-370-2. https://archive.org/details/professionalguid0000unse_o7n1/page/243. 
  45. ↑ 45.0 45.1 45.2 45.3 Walsh and Hoyt's clinical neuro-ophthalmology. Hagerstown, MD: Lippincott Williams & Wilkins. 2005. pp. 3264–65. ISBN 978-0-7817-4814-8. 
  46. ↑ "Case definitions for infectious conditions under public health surveillance. Centers for Disease Control and Prevention". MMWR. Recommendations and Reports 46 (RR-10): 1–55. May 1997. PMID 9148133. ftp://ftp.cdc.gov/pub/Publications/mmwr/rr/rr4610.pdf. Retrieved 11 November 2007. 
  47. ↑ 47.0 47.1 "Passive immunization against poliomyelitis". Monograph Series. World Health Organization 26: 357–70. 1955. PMID 14374581. 
  48. ↑ "Evaluation of Red Cross gamma globulin as a prophylactic agent for poliomyelitis. 5. Reanalysis of results based on laboratory-confirmed cases". Journal of the American Medical Association 156 (1): 21–27. September 1954. doi:10.1001/jama.1954.02950010023009. PMID 13183798. 
  49. ↑ "Passive immunization against poliomyelitis: the Hammon gamma globulin field trials, 1951–1953". American Journal of Public Health 95 (5): 790–99. May 2005. doi:10.2105/AJPH.2004.040790. PMID 15855454. 
  50. ↑ "Interview with Hilary Koprowski, sourced at History of Vaccines website". College of Physicians of Philadelphia. 15 October 2010. http://www.historyofvaccines.org/content/timelines/polio. 
  51. ↑ 51.0 51.1 51.2 "Polio Vaccine | IPV Vaccine". http://www.polio.info/polio-eradication/front/templates/index.jsp?siteCode=POLIO&codeRubrique=34&lang=EN.  Accessed 16 December 2009.
  52. ↑ "Tireless polio research effort bears fruit and indignation". The Salk vaccine: 50 years later/ second of two parts (Pittsburgh Post-Gazette). 4 April 2005. http://www.post-gazette.com/pg/05094/482468.stm. 
  53. ↑ "Pittsburgh Strong: Historic Tribute to a Vibrant Jewish Community". 29 October 2018. https://www.bh.org.il/blog-items/pittsburgh-strong-historic-tribute-to-a-vibrant-jewish-community/. 
  54. ↑ "History of Sabin attenuated poliovirus oral live vaccine strains". Journal of Biological Standardization 1 (2): 115–18. 1973. doi:10.1016/0092-1157(73)90048-6. 
  55. ↑ "Live, orally given poliovirus vaccine. Effects of rapid mass immunization on population under conditions of massive enteric infection with other viruses". JAMA 173 (14): 1521–26. August 1960. doi:10.1001/jama.1960.03020320001001. PMID 14440553. 
  56. ↑ 56.0 56.1 "A Science Odyssey: People and Discoveries". PBS. 1998. https://www.pbs.org/wgbh/aso/databank/entries/dm52sa.html. 
  57. ↑ "Transmissibility and persistence of oral polio vaccine viruses: implications for the global poliomyelitis eradication initiative". American Journal of Epidemiology 150 (10): 1001–21. November 1999. doi:10.1093/oxfordjournals.aje.a009924. PMID 10568615. 
  58. ↑ Alfaro-Murillo, Jorge A.; Ávila-Agüero, María L.; Fitzpatrick, Meagan C.; Crystal, Caroline J.; Falleiros-Arlant, Luiza-Helena; Galvani, Alison P. (2020-04-04). "The case for replacing the live oral polio vaccine with the inactivated vaccine throughout the Americas". Lancet 395 (10230): 1163–1166. doi:10.1016/S0140-6736(20)30213-0. ISSN 0140-6736. PMID 32247397. 
  59. ↑ "Poliomyelitis prevention: recommendations for use of inactivated poliovirus vaccine and live oral poliovirus vaccine. American Academy of Pediatrics Committee on Infectious Diseases". Pediatrics 99 (2): 300–05. February 1997. doi:10.1542/peds.99.2.300. PMID 9024465. http://pediatrics.aappublications.org/cgi/content/full/99/2/300. 
  60. ↑ "One hundred years of poliovirus pathogenesis". Virology 344 (1): 9–16. January 2006. doi:10.1016/j.virol.2005.09.015. PMID 16364730. 
  61. ↑ "Eradication of polio – Is Syria being left behind?". School of Public Health and Community Medicine. https://sphcm.med.unsw.edu.au/infectious-diseases-blog/eradication-polio-syria-being-left-behind. 
  62. ↑ "WHO: Vaccines for routine use". International travel and health. p. 12. https://www.who.int/ith/vaccines/2007_routine_use/en/index11.html. 
  63. ↑ Polio. Rochester, NY: University of Rochester Press. 1997. pp. 8–10. ISBN 978-1-58046-066-8. 
  64. ↑ 64.0 64.1 "Noninvasive mechanical ventilation at home: building upon the tradition". Chest 121 (2): 321–24. February 2002. doi:10.1378/chest.121.2.321. PMID 11834636. 
  65. ↑ Leboeuf C (1992). The late effects of Polio: Information For Health Care Providers.. Commonwealth Department of Community Services and Health. ISBN 1-875412-05-0. http://www.health.qld.gov.au/polio/. Retrieved 11 May 2007. 
  66. ↑ 66.0 66.1 66.2 66.3 "Polio: its impact on the people of the United States and the emerging profession of physical therapy". The Journal of Orthopaedic and Sports Physical Therapy 34 (8): 479–92. August 2004. doi:10.2519/jospt.2004.0301. PMID 15373011. http://www.post-polio.org/edu/hpros/Aug04HistPersNeumann.pdf.  Reproduced online with permission by Post-Polio Health International; retrieved on 10 November 2007.
  67. ↑ Physical Medicine and Rehabilitation Board Review. Demos Medical Publishing. 2004. ISBN 978-1-888799-45-3. https://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=physmedrehab.table.8357. 
  68. ↑ "Tracheotomy in bulbar poliomyelitis". California Medicine 72 (1): 34–36. January 1950. PMID 15398892. 
  69. ↑ Wackers, G. (1994). Constructivist Medicine (PhD thesis). Maastricht: Universitaire Pers Maastricht. Archived from the original on 23 December 2007. Retrieved 4 January 2008.
  70. ↑ "Comparison between concentric needle EMG and macro EMG in patients with a history of polio". Clinical Neurophysiology 110 (11): 1900–08. November 1999. doi:10.1016/S1388-2457(99)00150-9. PMID 10576485. 
  71. ↑ "Neural cell adhesion molecule in normal, denervated, and myopathic human muscle". Annals of Neurology 21 (5): 481–89. May 1987. doi:10.1002/ana.410210512. PMID 3296947. 
  72. ↑ 72.0 72.1 "Late effects of polio: critical review of the literature on neuromuscular function". Archives of Physical Medicine and Rehabilitation 72 (11): 923–31. October 1991. doi:10.1016/0003-9993(91)90013-9. PMID 1929813. 
  73. ↑ 73.0 73.1 73.2 "Post-poliomyelitis syndrome". Muscle & Nerve 31 (1): 6–19. January 2005. doi:10.1002/mus.20259. PMID 15599928. 
  74. ↑ 74.0 74.1 "Muscle adaptive changes in post-polio subjects". Scandinavian Journal of Rehabilitation Medicine 21 (1): 19–26. 1989. doi:10.2340/165019779891926. PMID 2711135. 
  75. ↑ 75.0 75.1 "Poliomyelitis virus (picornavirus, enterovirus), after-effects of the polio, paralysis, deformations". Polio Eradication. Sanofi Pasteur. http://www.polio.info/polio-eradication/front/index.jsp?siteCode=POLIO&lang=EN&codeRubrique=14. 
  76. ↑ 76.0 76.1 Mayo Clinic Staff (19 May 2005). "Polio: Complications". Mayo Foundation for Medical Education and Research (MFMER). http://www.mayoclinic.com/health/polio/DS00572/DSECTION=complications. 
  77. ↑ "Post-Polio Syndrome Fact Sheet: National Institute of Neurological Disorders and Stroke (NINDS)". http://www.ninds.nih.gov/disorders/post_polio/detail_post_polio.htm. 
  78. ↑ "Epidemiology of the post-polio syndrome". American Journal of Epidemiology 136 (7): 769–86. October 1992. doi:10.1093/aje/136.7.769. PMID 1442743. 
  79. ↑ "Post-poliomyelitis syndrome: case report and review of the literature". Annals of the Academy of Medicine, Singapore 34 (7): 447–49. August 2005. PMID 16123820. http://www.annals.edu.sg/pdf/34VolNo7200508/V34N7p447.pdf. 
  80. ↑ Orthoses for persons with postpolio syndrome.. AAOS Atlas of Orthoses and Assistive Devices. Philadelphia: Mosby/Elsevier. 2008. pp. 411–17. ISBN 978-0-323-03931-4. OCLC 152793635. https://musculoskeletalkey.com/orthoses-for-persons-with-postpolio-syndrome/. Retrieved 20 July 2021. 
  81. ↑ "Gait of stance control orthosis users: the dynamic knee brace system". Prosthetics and Orthotics International 29 (3): 269–82. December 2005. doi:10.1080/03093640500238915. PMID 16466156. 
  82. ↑ "Effect of carbon-composite knee-ankle-foot orthoses on walking efficiency and gait in former polio patients". Journal of Rehabilitation Medicine 39 (8): 651–7. October 2007. doi:10.2340/16501977-0110. PMID 17896058. 
  83. ↑ "Polio This Week". Global Polio Eradication Initiative (GPEI). http://polioeradication.org/polio-today/polio-now/this-week/. 
  84. ↑ "Polio Case Count". World Health Organization. http://apps.who.int/immunization_monitoring/en/diseases/poliomyelitis/case_count.cfm. 
  85. ↑ "The decade of the last recorded case of paralytic polio by country". https://ourworldindata.org/grapher/the-decade-of-the-last-recorded-case-of-paralytic-polio-by-country. 
  86. ↑ "Polio Vaccine Celebrates 60th Anniversary". 10 April 2015. https://www.rotary.org/en/polio-vaccine-celebrates-60th-anniversary. 
  87. ↑ "Driven to Extinction". 1 July 2015. http://www.the-scientist.com/?articles.view/articleNo/43382/title/Driven-to-Extinction/. 
  88. ↑ "Smallpox". WHO Factsheet. https://www.who.int/mediacentre/factsheets/smallpox/en/. 
  89. ↑ "The Smallpox Eradication Programme – SEP (1966–1980)". https://www.who.int/features/2010/smallpox/en/. 
  90. ↑ "No more deaths from rinderpest" (Press release). World Organisation for Animal Health. 25 May 2011. Archived from the original on 24 September 2015. Retrieved 11 November 2015.
  91. ↑ World Health Assembly (2012). Poliomyelitis: intensification of the global eradication initiative. Agenda item A65/20. Geneva, Switzerland: World Health Organization. http://apps.who.int/gb/ebwha/pdf_files/wha65/A65_20-en.pdf. Retrieved 7 December 2013. 
  92. ↑ Centers for Disease Control Prevention (CDC) (October 2006). "Update on vaccine-derived polioviruses". MMWR. Morbidity and Mortality Weekly Report 55 (40): 1093–7. PMID 17035927. 
  93. ↑ Centers for Disease Control and Prevention (CDC) (May 2008). "Progress toward interruption of wild poliovirus transmission—worldwide, January 2007 – April 2008". MMWR. Morbidity and Mortality Weekly Report 57 (18): 489–94. PMID 18463607. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5718a4.htm. 
  94. ↑ 94.0 94.1 94.2 "WHO South-East Asia Region certified polio-free". WHO. 27 March 2014. http://www.searo.who.int/mediacentre/releases/2014/pr1569/en/. 
  95. ↑ "Wild poliovirus type 1 and Circulating vaccine-derived poliovirus cases". 23 December 2015. http://www.polioeradication.org/dataandmonitoring/poliothisweek.aspx. 
  96. ↑ "Progress Toward Poliomyelitis Eradication – Afghanistan and Pakistan, January 2011 – August 2012". Centers for Disease Control and Prevention. 19 October 2012. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6139a4.htm. 
  97. ↑ "Polio: measuring the protection that matters most". The Journal of Infectious Diseases 200 (5): 673–5. September 2009. doi:10.1086/605331. PMID 19624277. 
  98. ↑ Wild Poliovirus case list 2000–2010; data in WHO/HQ as of 9 November 2010 "Emergency appeal for Congo polio outbreak". http://www.polioeradication.org/tabid/167/iid/80/Default.aspx. 
  99. ↑ "GPEI-Vaccine-Derived Polioviruses". https://polioeradication.org/polio-today/polio-prevention/the-virus/vaccine-derived-polio-viruses/. 
  100. ↑ "How Drone Strikes and a Fake Vaccination Program Have Inhibited Polio Eradication in Pakistan: An Analysis of National Level Data". International Journal of Health Services: Planning, Administration, Evaluation 47 (4): 807–25. October 2017. doi:10.1177/0020731417722888. ISSN 1541-4469. PMID 28764582. http://qmro.qmul.ac.uk/xmlui/handle/123456789/25135. Retrieved 4 May 2021. 
  101. ↑ "C.I.A. Vaccine Ruse May Have Harmed the War on Polio". The New York Times. 9 July 2012. ISSN 0362-4331. https://www.nytimes.com/2012/07/10/health/cia-vaccine-ruse-in-pakistan-may-have-harmed-polio-fight.html. 
  102. ↑ "Pakistan's fight against polio clashes with battle against Taliban – The National". 20 January 2015. http://www.thenational.ae/world/south-asia/pakistans-fight-against-polio-clashes-with-battle-against-taliban#page2. 
  103. ↑ 103.0 103.1 The National staff (18 April 2015). "UAE polio campaign vaccinates millions of Pakistani children". http://www.thenational.ae/uae/health/uae-polio-campaign-vaccinates-millions-of-pakistani-children. 
  104. ↑ "House-to-house polio vaccination set to recommence across Afghanistan in November". https://www.unicef.org/press-releases/house-house-polio-vaccination-set-recommence-across-afghanistan-november. 
  105. ↑ "Seven shot dead in Pakistan polio attack". BBC News. 20 April 2016. https://www.bbc.com/news/world-asia-36090891. 
  106. ↑ World Health Organization, Global Polio Eradication Initiative (2022-06-30). "Afghanistan Polio Eradication Initiative Annual Report 2021". https://polioeradication.org/wp-content/uploads/2022/06/Afghanistan-Annual-Report-2021.pdf. 
  107. ↑ "GPEI-Afghanistan" (in en-GB). https://polioeradication.org/where-we-work/afghanistan/. 
  108. ↑ "Nationwide polio campaign starts today". Dawn. 10 December 2018. https://www.dawn.com/news/1450490. "It shows that the number of annual polio cases has decreased by 97 per cent from 306 reported in 2014." 
  109. ↑ The National staff (24 January 2015). "17 million children to be vaccinated against polio in Pakistan". http://www.thenational.ae/uae/health/17-million-children-to-be-vaccinated-against-polio-in-pakistan. 
  110. ↑ "Pakistan could beat polio in months, says WHO". BBC News. 16 May 2016. https://www.bbc.co.uk/news/world-asia-36300034. 
  111. ↑ "Polio in Pakistan: Drop of 70% recorded this year". BBC News. 3 June 2015. https://www.bbc.com/news/world-asia-32996624. 
  112. ↑ Centers for Disease Control Prevention (CDC) (October 1994). "Certification of poliomyelitis eradication—the Americas, 1994". MMWR. Morbidity and Mortality Weekly Report 43 (39): 720–2. PMID 7522302. https://www.cdc.gov/mmwr/preview/mmwrhtml/00032760.htm. 
  113. ↑ "Polio Declared Eliminated from the Americas | History of Vaccines". https://www.historyofvaccines.org/content/polio-declared-eliminated-americas. 
  114. ↑ "Guidance to US Clinicians Regarding New WHO Polio Vaccination Requirements for Travel by Residents of and Long-term Visitors to Countries with Active Polio Transmission". 2 June 2014. http://emergency.cdc.gov/han/han00362.asp. 
  115. ↑ Kimball, Spencer (4 October 2022). "How polio came back to New York for the first time in decades, silently spread and left a patient paralyzed" (in en). https://www.cnbc.com/2022/10/04/how-polio-silently-spread-in-new-york-and-left-a-person-paralyzed.html. 
  116. ↑ "Wastewater Testing and Detection of Poliovirus Type 2 Genetically Linked to Virus Isolated from a Paralytic Polio Case — New York, March 9 – October 11, 2022". MMWR. Morbidity and Mortality Weekly Report 71 (44): 1418–1424. 2022. doi:10.15585/mmwr.mm7144e2. ISSN 0149-2195. PMID 36327157. PMC 9639435. https://www.cdc.gov/mmwr/volumes/71/wr/mm7144e2.htm. Retrieved 31 October 2022. 
  117. ↑ Ashwin, Vasan, MD, PhD (August 12, 2022). "2022 Health Alert #20: Update on Poliovirus in New York City". https://www1.nyc.gov/assets/doh/downloads/pdf/han/alert/2022/polio-in-nyc.pdf. 
  118. ↑ Yamazaki, S.; Toraya, H. (2001). "General News. Major Milestone reached in Global Polio Eradication: Western Pacific Region is certified Polio-Free". Health Education Research 16 (1): 109–114. doi:10.1093/her/16.1.109. Bibcode: 2001PDiff..16..110Y. 
  119. ↑ "Australia declared polio free". Communicable Diseases Intelligence Quarterly Report 26 (2): 253–60. 2002. PMID 12206379. 
  120. ↑ "New polio outbreak hits China - CNN.com". CNN. 21 September 2011. http://www.cnn.com/2011/09/21/health/china-polio-outbreak/index.html. 
  121. ↑ "PH declares polio outbreak as disease returns after 19 years". Rappler (Manila, Philippines). 19 September 2019. https://www.rappler.com/nation/240493-polio-back-philippines. 
  122. ↑ "WHO, UNICEF laud end of polio outbreak in the Philippines" (in en). https://www.who.int/philippines/news/detail/11-06-2021-who-unicef-laud-end-of-polio-outbreak-in-the-philippines. 
  123. ↑ "Malaysia Reports First Case of Polio in 27 Years". VOA News. Associated Press. 9 December 2019. https://www.voanews.com/science-health/malaysia-reports-first-case-polio-27-years. 
  124. ↑ "Polio wiped out in Malaysia, says KJ". Free Malaysia Today. 11 September 2021. https://www.freemalaysiatoday.com/category/nation/2021/09/11/polio-wiped-out-in-malaysia-says-kj/. 
  125. ↑ Snider, Cynthia J.; Boualam, Liliane; Tallis, Graham; Takashima, Yoshihiro; Abeyasinghe, Rabindra; Lo, Ying-Ru; Grabovac, Varja; Avagyan, Tigran et al. (2022-03-23). "Concurrent outbreaks of circulating vaccine-derived poliovirus types 1 and 2 affecting the Republic of the Philippines and Malaysia, 2019–2021" (in en). Vaccine 41 (Suppl 1): A58–A69. doi:10.1016/j.vaccine.2022.02.022. ISSN 0264-410X. PMID 35337673. 
  126. ↑ "Europe achieves historic milestone as Region is declared polio-free" (Press release). European Region of the World Health Organization. 21 June 2002. Archived from the original on 16 September 2008. Retrieved 23 August 2008.
  127. ↑ "Polio-free certification: WHO South-East Asia". 27 March 2014. http://www.searo.who.int/entity/immunization/topics/polio/eradication/sea-polio-free/en/. 
  128. ↑ "India wins battle against dreaded polio". Deccan Herald. 26 February 2012. 
  129. ↑ "India polio-free for a year: 'First time in history we're able to put up such a map'". The Telegraph (Calcutta, India). 26 February 2012. http://www.telegraphindia.com/1120226/jsp/frontpage/story_15181357.jsp. 
  130. ↑ "Polio in Syria: An outbreak that threatens the Middle East". BBC News. 26 March 2014. https://www.bbc.com/news/magazine-26734465. 
  131. ↑ "Syria polio cases spread to Damascus and Aleppo – WHO". DNA. 26 November 2013. http://www.dnaindia.com/health/report-syria-polio-cases-spread-to-damascus-and-aleppo-who-1925221. 
  132. ↑ "WHO: Polio cases confirmed in Syria". CNN.com. 29 October 2013. http://edition.cnn.com/2013/10/29/health/syria-polio/index.html. 
  133. ↑ "Syria's Polio Epidemic: The Suppressed Truth". New York Review. 20 February 2014. http://www.nybooks.com/articles/archives/2014/feb/20/syrias-polio-epidemic-suppressed-truth/?insrc=hpma. Retrieved 23 January 2014. "Ninety or so afflicted children may sound like a small number, but they are only a tiny manifestation of an enormous problem, since for each crippled child up to one thousand more are silently infected. Polio is so contagious that a single case is considered a public health emergency. Ninety cases could mean some 90,000 people infected, each a carrier invisibly spreading the disease to others for weeks on end.". 
  134. ↑ Motlagh, Jason (5 March 2015). "Fighting Polio Amid the Chaos of Syria's Civil War". National Geographic. http://news.nationalgeographic.com/2015/03/150305-polio-syria-iraq-islamic-state-refugees-vaccination-virus-jihad/. 
  135. ↑ "Polio immunisation rate in Syria close to pre-war level -WHO". Reuters. 28 January 2015. https://www.reuters.com/article/mideast-crisis-syria-polio-idUSL6N0V70ZW20150128. 
  136. ↑ "Polio Paralyzes 17 Children in Syria, W.H.O. Says". The New York Times. 20 June 2017. https://www.nytimes.com/2017/06/20/world/middleeast/syria-polio-children-paralyzed.html. 
  137. ↑ "Syria war: Polio paralyses 17 children in Mayadin and Raqqa". BBC News. 20 June 2017. https://www.bbc.com/news/world-middle-east-40342864. 
  138. ↑ "GPEI-Syrian Arab Republic" (in en-GB). https://polioeradication.org/where-we-work/syrian-arab-republic/. 
  139. ↑ "Polio Eradication Efforts in Nigeria and India". http://www.unicef.org/cbsc/index_49534.html. 
  140. ↑ "Nigeria polio vaccinators shot dead in Kano". BBC News. 8 February 2013. https://www.bbc.co.uk/news/world-africa-21381773. 
  141. ↑ "Nigeria marks one year without recorded polio case". BBC News. 24 July 2015. https://www.bbc.co.uk/news/world-africa-33650543. 
  142. ↑ "Nigeria marks polio-free year, raising global eradication hopes". Reuters. 23 July 2015. https://www.reuters.com/article/us-health-polio-nigeria-idUSKCN0PX2RF20150723. 
  143. ↑ "WHO Removes Nigeria from Polio-Endemic List". WHO. 26 September 2015. https://www.who.int/mediacentre/news/releases/2015/nigeria-polio/en/. 
  144. ↑ "Government of Nigeria reports 2 wild polio cases, first since July 2014". 11 August 2016. https://www.who.int/mediacentre/news/releases/2016/nigeria-polio/en/. 
  145. ↑ Guglielmi, Giorgia (2020-08-28). "Africa declared free from wild polio — but vaccine-derived strains remain" (in en). Nature. doi:10.1038/d41586-020-02501-3. PMID 32860027. https://www.nature.com/articles/d41586-020-02501-3. Retrieved 1 July 2022. 
  146. ↑ "Malawi declares polio outbreak" (in en). https://www.afro.who.int/news/malawi-declares-polio-outbreak. 
  147. ↑ "First polio outbreak in 30 years declared in Mozambique" (in en). 2022-05-18. https://news.un.org/en/story/2022/05/1118502. 
  148. ↑ Paul JR (1971). A History of Poliomyelitis. Yale studies in the history of science and medicine. New Haven, Conn: Yale University Press. pp. 16–18. ISBN 978-0-300-01324-5. 
  149. ↑ Renfrew, Colin; Bahn, Paul (2012). Archaeology: Theories, Methods, and Practice (6th ed.). Thames & Hudson. pp. 447. ISBN 978-0-500-28976-1. 
  150. ↑ Underwood M (1789). "Debility of the lower extremities". A treatise on the diseases of children, with general directions for the management of infants from the birth (1789). 2. London: J. Mathews. pp. 88–91. https://archive.org/stream/b21516728_0002#page/n103/mode/2up. 
  151. ↑ "Poliomyelitis (Heine–Medin disease)". Journal of Neurology, Neurosurgery, and Psychiatry 76 (1): 128. January 2005. doi:10.1136/jnnp.2003.028548. PMID 15608013. 
  152. ↑ Robertson S (1993). "Module 6: Poliomyelitis" (PDF). The Immunological Basis for Immunization Series. World Health Organization. Geneva, Switzerland.. http://whqlibdoc.who.int/hq/1993/WHO_EPI_GEN_93.16_mod6.pdf?ua=1. 
  153. ↑ 153.0 153.1 "The Spatial Dynamics of Poliomyelitis in the United States: From Epidemic Emergence to Vaccine-Induced Retreat, 1910–1971". Annals of the Association of American Geographers 95 (2): 269–93. June 2005. doi:10.1111/j.1467-8306.2005.00460.x. PMID 16741562. 
  154. ↑ Melnick JL (1990). Poliomyelitis. In: Tropical and Geographical Medicine (2nd ed.). McGraw-Hill. pp. 558–76. ISBN 978-0-07-068328-0. 
  155. ↑ Zamula E (1991). "A New Challenge for Former Polio Patients". FDA Consumer 25 (5): 21–25. https://www.questia.com/library/1G1-10942759/a-new-challenge-for-former-polio-patients. 
  156. ↑ "Louise Reisner-Sénélar (2009) The Danish anaesthesiologist Björn Ibsen a pioneer of long-term ventilation on the upper airways". https://docs.google.com/viewer?a=v&pid=explorer&chrome=true&srcid=0B7CdB217pf6yN2QxOGI5NTUtZWIzYS00N2NhLWFhODQtOGZjMjdhZTlkZGE5. 
  157. ↑ Elsevier, ed (2007). "Bjørn Aage Ibsen". The Lancet 370 (9598): 1538. doi:10.1016/S0140-6736(07)61650-X. 
  158. ↑ 158.0 158.1 "After Effects of Polio Can Harm Survivors 40 Years Later". March of Dimes. 1 June 2001. http://www.marchofdimes.org/news/after-effects-of-polio-can-harm-survivors-40-years-later.aspx. 
  159. ↑ "Post-polio sequelae: physiological and psychological overview". Rehabilitation Literature 47 (5–6): 106–11. 1986. PMID 3749588. 
  160. ↑ The Polio Paradox: Understanding and Treating "Post-Polio Syndrome" and Chronic Fatigue. New York: Warner Books. 2002. pp. 105–06. ISBN 978-0-446-69069-0. 
  161. ↑ "Four added to Polio Hall of Fame at Warm Springs". The Times-Herald (Newnan, GA). 15 November 2008. http://www.times-herald.com/Local/Four-added-to-Polio-Hall-of-Fame-at-Warm-Springs-589785. 
  162. ↑ "CDC Inducted into Polio Hall of Fame". CDC in the News. 23 January 2009. https://www.cdc.gov/news/2009/01/polio_hof/. 
  163. ↑ "Announcement: World Polio Day – 24 October 2012". Centers for Disease Control and Prevention. 19 October 2012. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6141a6.htm. 
  164. ↑ "Combating enterovirus replication: state-of-the-art on antiviral research". Biochemical Pharmacology 83 (2): 185–92. January 2012. doi:10.1016/j.bcp.2011.08.016. PMID 21889497. 
  165. ↑ "Progress in the development of poliovirus antiviral agents and their essential role in reducing risks that threaten eradication". The Journal of Infectious Diseases 210 (Suppl 1): S447–53. November 2014. doi:10.1093/infdis/jiu043. PMID 25316866. 
  166. ↑ "GPEI-Antivirals" (in en-GB). http://polioeradication.org/tools-and-library/research-innovation/antivirals/. 

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