Biology:40S ribosomal protein S18
 Generic protein structure example |
40S ribosomal protein S18 is a protein that in humans is encoded by the RPS18 gene.[1][2][3]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]
References
- ↑ "The human homolog of ribosomal protein S18". Nucleic Acids Res 21 (3): 745. Mar 1993. doi:10.1093/nar/21.3.745. PMID 8441687.
- ↑ "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. Aug 1998. doi:10.1101/gr.8.5.509. PMID 9582194.
- ↑ 3.0 3.1 "Entrez Gene: RPS18 ribosomal protein S18". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6222.
Further reading
- "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11–12): 933–47. 1996. doi:10.1139/o95-101. PMID 8722009.
- "The primary structure of rat ribosomal protein S18.". Biochem. Biophys. Res. Commun. 178 (3): 1212–8. 1991. doi:10.1016/0006-291X(91)91022-5. PMID 1872840.
- "Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts.". Cancer Res. 54 (19): 5217–23. 1994. PMID 7923143.
- "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.". Eur. J. Biochem. 239 (1): 144–9. 1996. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
- "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. 2002. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- "The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II.". J. Biol. Chem. 277 (37): 33537–40. 2002. doi:10.1074/jbc.C200342200. PMID 12145273.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404. Bibcode: 2003Natur.425..805M.
- "Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library.". Mol. Cell. Biochem. 262 (1–2): 187–93. 2005. doi:10.1023/B:MCBI.0000038234.35936.1c. PMID 15532723.
- "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes.". Protein Sci. 14 (6): 1438–46. 2005. doi:10.1110/ps.041293005. PMID 15883184.
External links
- Overview of all the structural information available in the PDB for UniProt: P62269 (40S ribosomal protein S18) at the PDBe-KB.
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