Biology:MT-RNR2

From HandWiki
Short description: Human gene
mitochondrially encoded 16S RNA
Identifiers
SymbolMT-RNR2
Alt. symbolsMTRNR2
NCBI gene4550
HGNC7471
UniProtQ8IVG9
Other data
LocusChr. MT [1]
Location of the MT-RNR2 gene on the H strand of the human mitochondrial genome. MT-RNR2, or RRNL, is one of the two mitochondrial ribosomal RNA genes (blue boxes).

Mitochondrially encoded 16S RNA (often abbreviated as 16S) is the mitochondrial large subunit ribosomal RNA[1][2] that in humans is encoded by the MT-RNR2 gene. The MT-RNR2 gene also encodes the Humanin polypeptide that has been the target of Alzheimer's disease research.[3]

The 16S rRNA is the mitochondrial homologue of the prokaryotic 23S and eukaryotic nuclear 28S ribosomal RNAs.[4]

See also

References

  1. "Mitochondrial 16S rRNA sequence diversity of hominoids". The Journal of Heredity 92 (6): 490–496. 2001. doi:10.1093/jhered/92.6.490. PMID 11948216. 
  2. "Mutations of mtDNA in renal cell tumours arising in end-stage renal disease". The Journal of Pathology 199 (2): 237–242. February 2003. doi:10.1002/path.1273. PMID 12533837. 
  3. "Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults". Neuroscience Letters 324 (3): 227–231. May 2002. doi:10.1016/S0304-3940(02)00199-4. PMID 12009529. 
  4. "Distinctive sequence of human mitochondrial ribosomal RNA genes". Nature 286 (5772): 460–467. July 1980. doi:10.1038/286460a0. PMID 6157106. Bibcode1980Natur.286..460E.