Biology:MRPS7
 Generic protein structure example |
28S ribosomal protein S7, mitochondrial is a protein that in humans is encoded by the MRPS7 gene.[1]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p.[1]
References
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–174. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–156. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Identification of a mammalian mitochondrial homolog of ribosomal protein S7.". Biochem. Biophys. Res. Commun. 266 (1): 141–146. 2000. doi:10.1006/bbrc.1999.1785. PMID 10581179.
- "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–1560. 2001. doi:10.1101/gr.140200. PMID 11042152.
- "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present.". J. Biol. Chem. 276 (22): 19363–19374. 2001. doi:10.1074/jbc.M100727200. PMID 11279123.
- "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit.". J. Biol. Chem. 276 (35): 33181–33195. 2001. doi:10.1074/jbc.M103236200. PMID 11402041.
- "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1–2): 65–70. 2001. doi:10.1006/geno.2001.6622. PMID 11543634.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468–480. 2003. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–2127. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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