Chemistry:Centaureidin

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Centaureidin
Chemical structure of centaureidin
Names
IUPAC name
3′,5,7-Trihydroxy-3,4′,6-trimethoxyflavone
Systematic IUPAC name
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6-dimethoxy-4H-1-benzopyran-4-one
Other names
Desmethoxycentaureidine
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
UNII
Properties
C18H16O8
Molar mass 360.31 g/mol
Density 1.542 g/mL
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
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Centaureidin is an O-methylated flavonol. It can be isolated from Tanacetum microphyllum,[1] Achillea millefolium,[2] Brickellia veronicaefolia, Bidens pilosa[3] and Polymnia fruticosa.[4]

References

  1. Abad, Maria Jose; Bermejo, Paulina; Villar, Angel (1995). "The activity of flavonoids extracted from Tanacetum microphyllum DC. (Compositae) on soybean lipoxygenase and prostaglandin synthetase". General Pharmacology: The Vascular System 26 (4): 815–9. doi:10.1016/0306-3623(94)00242-F. PMID 7635257. 
  2. "Assessment Report on Achillea Millefolium L., Herba". 15 September 2010. https://www.ema.europa.eu/documents/herbal-report/draft-assessment-report-achillea-millefolium-l-herba_en.pdf. 
  3. Chang, Shu-Lin; Chiang, Yi-Ming; Chang, Cicero Lee-Tian; Yeh, Hsu-Hua; Shyur, Lie-Fen; Kuo, Yueh-Hsiung; Wu, Tung-Kung; Yang, Wen-Chin (2007). "Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-γ expression". Journal of Ethnopharmacology 112 (2): 232–6. doi:10.1016/j.jep.2007.03.001. PMID 17408892. 
  4. Beutler, John A.; Cardellina, John H.; Lin, Chii M.; Hamel, Ernest; Cragg, Gordon M.; Boyd, Michael R. (1993). "Centaureidin, a cytotoxic flavone from Polymnia fruticosa, inhibits tubulin polymerization". Bioorganic & Medicinal Chemistry Letters 3 (4): 581–4. doi:10.1016/S0960-894X(01)81233-6.