Chemistry:Galangin

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Galangin is a flavonol, a type of flavonoid.

Occurrence

Galangin is found in high concentrations in plants like Alpinia officinarum (lesser galangal)[1] and Helichrysum aureonitens.[2] It is also found in the rhizome of Alpinia galanga[3] and in propolis.[4]

Biological activities

Galangin has been shown to have in vitro antibacterial[5][6][7] and antiviral activity.[8] It also inhibits the growth of breast tumor cells in vitro.[9][10]

References

  1. ↑ Ciolino, H. P.; Yeh, G. C. (1999). "The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor". British Journal of Cancer 79 (9/10): 1340–1346. doi:10.1038/sj.bjc.6690216. PMID 10188874. 
  2. ↑ "The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens". Journal of Ethnopharmacology 57 (3): 177–181. 1997. doi:10.1016/s0378-8741(97)00065-2. PMID 9292410. 
  3. ↑ Kaur, A.; Singh, R.; Dey, C. S.; Sharma, S. S.; Bhutani, K. K.; Singh, I. P. (2010). "Antileishmanial phenylpropanoids from Alpinia galanga (Linn.) Willd". Indian Journal of Experimental Biology 48 (3): 314–317. PMID 21046987. http://nopr.niscair.res.in/bitstream/123456789/7407/1/IJEB%2048(3)%20314-317.pdf. 
  4. ↑ Tosi, E; Re, E; Ortega, M; Cazzoli, A (2007). "Food preservative based on propolis: Bacteriostatic activity of propolis polyphenols and flavonoids upon Escherichia coli". Food Chemistry 104 (3): 1025–1029. doi:10.1016/j.foodchem.2007.01.011. 
  5. ↑ "Assessment of the antibacterial activity of galangin against 4-quinolone resistant strains of Staphylococcus aureus". Phytomedicine 13 (3): 187–191. 2006. doi:10.1016/j.phymed.2004.07.003. PMID 16428027. https://hal.science/hal-04842337. 
  6. ↑ "Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss". Journal of Ethnopharmacology 101 (1–3): 243–248. 2005. doi:10.1016/j.jep.2005.04.014. PMID 15985350. https://hal.science/hal-04842111. 
  7. ↑ Liu, Yang Sylvia; Zhang, Chengqian; Khoo, Bee Luan; Hao, Piliang; Chua, Song Lin (2024-09-02). "Dual-species proteomics and targeted intervention of animal-pathogen interactions". Journal of Advanced Research. doi:10.1016/j.jare.2024.08.038. ISSN 2090-1232. PMID 39233003. PMC 12225907. https://www.sciencedirect.com/science/article/pii/S2090123224003837. 
  8. ↑ "Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens". Journal of Ethnopharmacology 56 (2): 165–169. 1997. doi:10.1016/s0378-8741(97)01514-6. PMID 917497. 
  9. ↑ So, F. V.; Guthrie, N.; Chambers, A. F.; Moussa, M.; Carroll, K. K. (1996). "Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices". Nutrition and Cancer 26 (2): 167–181. doi:10.1080/01635589609514473. PMID 8875554. 
  10. ↑ So, F.; Guthrie, N.; Chambers, A. F.; Carroll, K. K. (1997). "Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen". Cancer Letters 112 (2): 127–133. doi:10.1016/S0304-3835(96)04557-0. PMID 9066718. 



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