Chemistry:Fenoverine
From HandWiki
Short description: Chemical compound
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| Formula | C26H15N3O3S |
| Molar mass | 449.48 g·mol−1 |
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Fenoverine (INN) is an antispasmodic [also known as spasmolytics] drug,[1] which acts by inhibiting calcium channels[2] [much in the same way as traditional calcium channel blockers, which are used as antianginal drugs]. In the case of Fenoverine, the relaxation occurs in abdominal / intestinal smooth muscles, while in case of antianginal drugs, the relaxation occurs in coronary vessels. Notably Fenoverine does not act as an antianginal agent.
Toxicity
Fenoverine is known to cause rhabdomyolysis.[2][3]
References
- ↑ "Effect of antispasmodic agents, alone or in combination, in the treatment of Irritable Bowel Syndrome: systematic review and meta-analysis". Revista de Gastroenterologia de Mexico 77 (2): 82–90. 2012. doi:10.1016/j.rgmx.2012.04.002. PMID 22672854.
- ↑ 2.0 2.1 "Fenoverine-induced rhabdomyolysis". Hum Exp Toxicol 14 (8): 654–656. August 1995. doi:10.1177/096032719501400805. PMID 7576832.
- ↑ "The incidence, risk factors, and clinical outcomes of rhabdomyolysis associated with fenoverine prescription: a retrospective study in South Korea (1999-2014)". BMC Pharmacol Toxicol 21 (1): 30. April 2020. doi:10.1186/s40360-020-00408-3. PMID 32334639.
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