Chemistry:Otilonium bromide
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| Trade names | Spasmoctyl 40, Doralin |
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| Formula | C29H43BrN2O4 |
| Molar mass | 563.577 g·mol−1 |
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Otilonium bromide, sold under the trade name Spasmomen among others, is an antimuscarinic and calcium channel blocker used to relieve spasmodic pain of the gut, especially in irritable bowel syndrome.[1] This means it works in the gut themselves, by relaxing the small muscles of the intestines, which results in relieving cramps and therefore reduces pain.
Medical uses
A pooled analysis of three clinical trials suggest that otilonium is more effective than placebo for the treatment of irritable bowel syndrome.[2]
Pharmacology
Otilinium binds to both muscarinic receptors and tachykinin NK2 receptors.[3] It has been shown to inhibit L-type and T-type calcium channels, actions which may contribute to or determine its effects in the gut.[4][5]
When taken orally, very little of the drug is absorbed into the rest of the body,[6] which means that most of its actions remain confined to the gastrointestinal system.
References
- ↑ "Dismox". http://www.grupounipharm.com/sites/default/files/DISMOX+Inserto+CORREGIDO+2011.+Ingl%C3%A9s.pdf.
- ↑ "Efficacy of otilonium bromide in irritable bowel syndrome: a pooled analysis". Therapeutic Advances in Gastroenterology 10 (3): 311–322. March 2017. doi:10.1177/1756283X16681708. PMID 28246548.
- ↑ "Otilonium bromide: a selective spasmolytic for the gastrointestinal tract". The Journal of International Medical Research 27 (5): 207–22. 1999. doi:10.1177/030006059902700501. PMID 10689627.
- ↑ "Otilonium bromide inhibits muscle contractions via L-type calcium channels in the rat colon". Neurogastroenterology and Motility 16 (2): 175–83. April 2004. doi:10.1111/j.1365-2982.2004.00518.x. PMID 15086871.
- ↑ "T-type Ca(2+) channel modulation by otilonium bromide". American Journal of Physiology. Gastrointestinal and Liver Physiology 298 (5): G706-13. May 2010. doi:10.1152/ajpgi.00437.2009. PMID 20203058.
- ↑ "Oral bioavailability and enterohepatic recirculation of otilonium bromide in rats". Archives of Pharmacal Research 31 (1): 117–24. January 2008. doi:10.1007/s12272-008-1129-2. PMID 18277617.
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