Chemistry:Rociverine
From HandWiki
Rociverine is an antispasmodic drug used to treat urinary, gastrointestinal and biliary spasms.[1] It is antimuscarinic drug.[2]
Medical uses
In India, rociverine is used as part of the "Programmed Labour Protocol" to help reduce pain and shorten the duration of labor. However, an analysis of clinical trials provides little evidence supporting its effectiveness in reducing labor duration.[3]
Pharmacology
The (1R,2R) stereoisomer showed 240-fold greater affinity for the muscarinic receptor, but the (1S,2S) compound showed the best selectivity.[4]
References
- ↑ "Rociverine". https://go.drugbank.com/drugs/DB13581.
- ↑ "Rociverine, a new antispasmodic agent with balanced neurotropic and myotropic activity". Arzneimittel-Forschung 28 (7): 1130–42. 1978. PMID 582702.
- ↑ "Antispasmodics for labour". The Cochrane Database of Systematic Reviews 2013 (6). June 2013. doi:10.1002/14651858.CD009243.pub3. PMID 23737030.
- ↑ "Stereoselective inhibition of muscarinic receptor subtypes by the eight stereoisomers related to rociverine". European Journal of Pharmacology 290 (2): 125–132. July 1995. doi:10.1016/0922-4106(95)90024-1. PMID 8575526.
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