Chemistry:Clebopride

Short description: Dopamine antagonist drug

Clebopride

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	A03FA06 (WHO)
Identifiers
IUPAC name 4-amino-N-(1-benzylpiperidin-4-yl)-5-chloro- 2-methoxybenzamide
CAS Number	55905-53-8 Y
PubChem CID	2780
ChemSpider	2678 Y
UNII	I0A84520Y9
KEGG	D03534 Y
ChEMBL	ChEMBL325109 Y
Chemical and physical data
Formula	C20H24ClN3O2
Molar mass	373.88 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1cc(c(OC)cc1N)C(=O)NC3CCN(Cc2ccccc2)CC3
InChI InChI=1S/C20H24ClN3O2/c1-26-19-12-18(22)17(21)11-16(19)20(25)23-15-7-9-24(10-8-15)13-14-5-3-2-4-6-14/h2-6,11-12,15H,7-10,13,22H2,1H3,(H,23,25) Y Key:BVPWJMCABCPUQY-UHFFFAOYSA-N Y
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Clebopride is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders. Chemically, it is a substituted benzamide, closely related to metoclopramide.

A small Spanish study found that more adverse reactions are reported with clebopride than with metoclopramide, particularly extrapyramidal symptoms.