Chemistry:Fenpiverinium
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Short description: Chemical compound
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| Formula | C22H29N2O+ |
| Molar mass | 337.487 g·mol−1 |
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Fenpiverinium is an anticholinergic and antispasmodic compound;[1] it is marketed as a combination drug with pitofenone hydrochloride and either nimesulide or metamizole in Eastern Europe and India to treat smooth muscle spasms and pain.[2]
The combination with metamizole was removed from the market in Lithuania for safety reasons in 2000[3] and a boxed warning against use by children and adolescents was added in Serbia in 2005.[4] In 2016 India banned marketing of the combination with nimesulide along with 344 other combination drugs;[5][6] the order was overturned in December and appealed by the Government in January 2017.[7]
References
- ↑ "Proposed INNs List 26". WHO Chronicle 25 (9). 1971. https://www.who.int/medicines/publications/druginformation/innlists/PL26.pdf?ua=1.. "Recommended INNs List 12". WHO Chronicle 26 (10). 1973. https://www.who.int/medicines/publications/druginformation/innlists/RL12.pdf?ua=1.
- ↑ (in en) Piperidine-Based Drug Discovery. Elsevier. 2017. ISBN 9780128134283. https://books.google.com/books?id=szxHDgAAQBAJ&pg=PA96.
- ↑ Consolidated List of Products - Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or Not Approved by Governments, Twelfth Issue. WHO. 2005. p. 305. http://apps.who.int/medicinedocs/en/m/abstract/Js16780e/.
- ↑ Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments, Fourteenth Issue. WHO. 2009. p. 35. http://apps.who.int/medicinedocs/en/m/abstract/Js16779e/.[|permanent dead link|dead link}}]
- ↑ "Health ministry bans 344 fixed dose combination drugs". The Times of India. March 14, 2016. http://timesofindia.indiatimes.com/good-governance/centre/Health-ministry-bans-344-fixed-dose-combination-drugs/articleshow/51394051.cms.
- ↑ "Gazette of India D. L.-33004/99. PART II—Section 3—Sub-section (ii)". Government of India. March 10, 2016. http://cdsco.nic.in/writereaddata/SO%20705(E)%20TO%201048(E)%20DATED%2010-03-2016.pdf.
- ↑ "Govt moves SC to enforce ban on 344 Fixed Dose Combination drugs". The Times of India. January 31, 2017. http://timesofindia.indiatimes.com/india/govt-moves-sc-to-enforce-ban-on-344-fixed-dose-combination-drugs/articleshow/56882858.cms.
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