Biology:Cyclic-guanylate-specific phosphodiesterase
From HandWiki
| Cyclic-guanylate-specific phosphodiesterase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.1.4.52 | ||||||||
| CAS number | 338732-46-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Cyclic-guanylate-specific phosphodiesterase (EC 3.1.4.52, cyclic bis(3′→5')diguanylate phosphodiesterase, c-di-GMP-specific phosphodiesterase, c-di-GMP phosphodiesterase, phosphodiesterase, phosphodiesterase A1, PDEA1, VieA) is an enzyme with systematic name cyclic bis(3′→5′)diguanylate 3-guanylylhydrolase.[1][2][3][4][5] This enzyme catalyses the following reaction:
- cyclic di-3′,5′-guanylate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 5′-phosphoguanylyl(3′→5′)guanosine
This enzyme requires Mg2+ or Mn2+ for activity. It is inhibited by Ca2+ and Zn2+.
References
- ↑ Chang, A.L.; Tuckerman, J.R.; Gonzalez, G.; Mayer, R.; Weinhouse, H.; Volman, G.; Amikam, D.; Benziman, M. et al. (2001). "Phosphodiesterase A1, a regulator of cellulose synthesis in Acetobacter xylinum, is a heme-based sensor". Biochemistry 40 (12): 3420–3426. doi:10.1021/bi0100236. PMID 11297407.
- ↑ Christen, M.; Christen, B.; Folcher, M.; Schauerte, A.; Jenal, U. (2005). "Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP". J. Biol. Chem. 280 (35): 30829–30837. doi:10.1074/jbc.M504429200. PMID 15994307.
- ↑ Schmidt, A.J.; Ryjenkov, D.A.; Gomelsky, M. (2005). "The ubiquitous protein domain EAL is a cyclic diguanylate-specific phosphodiesterase: enzymatically active and inactive EAL domains". J. Bacteriol. 187 (14): 4774–4781. doi:10.1128/JB.187.14.4774-4781.2005. PMID 15995192.
- ↑ Tamayo, R.; Tischler, A.D.; Camilli, A. (2005). "The EAL domain protein VieA is a cyclic diguanylate phosphodiesterase". J. Biol. Chem. 280 (39): 33324–33330. doi:10.1074/jbc.M506500200. PMID 16081414.
- ↑ "Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles". Nature Communications 5: 4462. 2014. doi:10.1038/ncomms5462. PMID 25042103.
External links
- Cyclic-guanylate-specific+phosphodiesterase at the US National Library of Medicine Medical Subject Headings (MeSH)
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