Biology:CYP105 family
From HandWiki
Short description: Group of cytochrome P450 enzymes
The evolutionary divergence of the CYP superfamily collected in 1990, CYP105A, B and C is in the branch of prokaryotic CYPs[1]
Cytochrome P450, family 105, also known as CYP105, is a cytochrome P450 monooxygenase family in bacteria, predominantly found in the phylum Actinomycetota and the order Actinomycetales.[2][3] The first three genes and subfamilies identified in this family is the herbicide-inducible P-450SU1 (CYP105A1, subfamily A) and P-450SU2 (CYP105B1, subfamily B) from Streptomyces griseolus[4][5] and choP (CYP105C1, subfamily C) from Streptomyces sp's cholesterol oxidase promoter region.[6][1]
Subfamily
| Subfamily[7] | first gene identified | Species | REF |
|---|---|---|---|
| A | SU1 (CYP105A1) | Streptomyces griseolus | [4] |
| B | SU2 (CYP105B1) | Streptomyces griseolus | [4] |
| C | choP (CYP105C1) | Streptomyces sp | [6] |
| D | soyC (CYP105D1) | Streptomyces griseus | [8] |
| E | ORF1 (CYP105E1) | Rhodococcus fascians | [9] |
Application
CYP105 enzymes is widely used in industry, such as the production of pravastatin.[3]
References
- ↑ 1.0 1.1 Nebert, DW; Nelson, DR; Coon, MJ; Estabrook, RW; Feyereisen, R; Fujii-Kuriyama, Y; Gonzalez, FJ; Guengerich, FP et al. (January 1991). "The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.". DNA and Cell Biology 10 (1): 1–14. doi:10.1089/dna.1991.10.1. PMID 1991046.
- ↑ "CYP105-diverse structures, functions and roles in an intriguing family of enzymes in Streptomyces". Journal of Applied Microbiology 117 (6): 1549–63. December 2014. doi:10.1111/jam.12662. PMID 25294646.
- ↑ 3.0 3.1 Yasuda, K; Sugimoto, H; Hayashi, K; Takita, T; Yasukawa, K; Ohta, M; Kamakura, M; Ikushiro, S et al. (January 2018). "Protein engineering of CYP105s for their industrial uses.". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1866 (1): 23–31. doi:10.1016/j.bbapap.2017.05.014. PMID 28583351.
- ↑ 4.0 4.1 4.2 Omer, CA; Lenstra, R; Litle, PJ; Dean, C; Tepperman, JM; Leto, KJ; Romesser, JA; O'Keefe, DP (June 1990). "Genes for two herbicide-inducible cytochromes P-450 from Streptomyces griseolus.". Journal of Bacteriology 172 (6): 3335–45. doi:10.1128/jb.172.6.3335-3345.1990. PMID 2345149.
- ↑ Hussain, HA; Ward, JM (January 2003). "Enhanced heterologous expression of two Streptomyces griseolus cytochrome P450s and Streptomyces coelicolor ferredoxin reductase as potentially efficient hydroxylation catalysts.". Applied and Environmental Microbiology 69 (1): 373–82. doi:10.1128/aem.69.1.373-382.2003. PMID 12514018. Bibcode: 2003ApEnM..69..373H.
- ↑ 6.0 6.1 Horii, M; Ishizaki, T; Paik, SY; Manome, T; Murooka, Y (July 1990). "An operon containing the genes for cholesterol oxidase and a cytochrome P-450-like protein from a Streptomyces sp.". Journal of Bacteriology 172 (7): 3644–53. doi:10.1128/jb.172.7.3644-3653.1990. PMID 2361941.
- ↑ Cytochrome P450 Homepage Link
- ↑ Trower, MK; Lenstra, R; Omer, C; Buchholz, SE; Sariaslani, FS (August 1992). "Cloning, nucleotide sequence determination and expression of the genes encoding cytochrome P-450soy (soyC) and ferredoxinsoy (soyB) from Streptomyces griseus.". Molecular Microbiology 6 (15): 2125–34. doi:10.1111/j.1365-2958.1992.tb01386.x. PMID 1406253.
- ↑ Crespi, M; Vereecke, D; Temmerman, W; Van Montagu, M; Desomer, J (May 1994). "The fas operon of Rhodococcus fascians encodes new genes required for efficient fasciation of host plants.". Journal of Bacteriology 176 (9): 2492–501. doi:10.1128/jb.176.9.2492-2501.1994. PMID 8169198.
 |  |
