Biology:Alkylacetylglycerophosphatase

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alkylacetylglycerophosphatase
Identifiers
EC number3.1.3.59
CAS number102925-45-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme alkylacetylglycerophosphatase (EC 3.1.3.59) catalyzes the reaction

1-alkyl-2-acetyl-sn-glycero-3-phosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 1-alkyl-2-acetyl-sn-glycerol + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase. Other names in common use include 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase, and alkylacetylglycerophosphate phosphatase. This enzyme participates in ether lipid metabolism.

References

  • "A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen". J. Biol. Chem. 261 (12): 5373–7. 1986. PMID 3007498.