Biology:Xylulokinase

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xylulokinase
4bc2.jpg
D-xylulokinase monomer, Human
Identifiers
EC number2.7.1.17
CAS number9030-58-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a xylulokinase (EC 2.7.1.17) is an enzyme that catalyzes the chemical reaction

ATP + D-xylulose ⇌ ADP + D-xylulose 5-phosphate

Thus, the two substrates of this enzyme are ATP and D-xylulose, whereas its two products are ADP and D-xylulose 5-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:D-xylulose 5-phosphotransferase. Other names in common use include xylulokinase (phosphorylating), and D-xylulokinase. This enzyme participates in pentose and glucuronate interconversions.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2ITM and 2NLX.

Applications

Hydrogen production

In 2014 a low-temperature 50 °C (122 °F), atmospheric-pressure enzyme-driven process to convert xylose into hydrogen with nearly 100% of the theoretical yield was announced. The process employs 13 enzymes, including xylulokinase.[1][2]

References

  1. Martín Del Campo, J. S.; Rollin, J.; Myung, S.; Chun, Y.; Chandrayan, S.; Patiño, R.; Adams, M. W.; Zhang, Y. H. (2013-04-03). "Virginia Tech team develops process for high-yield production of hydrogen from xylose under mild conditions". Angewandte Chemie International Edition in English (Green Car Congress) 52 (17): 4587–90. doi:10.1002/anie.201300766. PMID 23512726. http://www.greencarcongress.com/2013/04/vt-20130403.html. Retrieved 2014-01-22. 
  2. "High-yield production of dihydrogen from xylose by using a synthetic enzyme cascade in a cell-free system". Angewandte Chemie 52 (17): 4587–90. April 2013. doi:10.1002/anie.201300766. PMID 23512726. 

Further reading