Biology:Acetylsalicylate deacetylase
From HandWiki
Short description: Class of enzymes
| acetylsalicylate deacetylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.1.55 | ||||||||
| CAS number | 87348-04-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme acetylsalicylate deacetylase (EC 3.1.1.55) catalyzes the reaction
- acetylsalicylate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] salicylate + acetate
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is acetylsalicylate O-acetylhydrolase. Other names in common use include aspirin esterase, acetylsalicylic acid esterase, and aspirin hydrolase.
References
- "Mammalian tissue acetylsalicylic acid esterase(s): identification, distribution and discrimination from other esterases". J. Pharmacol. Exp. Ther. 226 (2): 589–94. 1983. PMID 6875867.
- "Aspirin hydrolyzing esterases from rat liver cytosol". Biochem. Pharmacol. 40 (3): 481–7. 1990. doi:10.1016/0006-2952(90)90546-W. PMID 2383281. https://zenodo.org/record/1253820.
- "Partial purification and characterization of a microsomal carboxylesterase specific for salicylate esters from guinea-pig liver". Biochim. Biophys. Acta 785 (3): 138–47. 1984. doi:10.1016/0167-4838(84)90138-9. PMID 6704404.
 |  |
