Biology:Aminoacyl-tRNA hydrolase
From HandWiki
aminoacyl-tRNA hydrolase | |||||||||
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Identifiers | |||||||||
EC number | 3.1.1.29 | ||||||||
CAS number | 9054-98-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme aminoacyl-tRNA hydrolase (EC 3.1.1.29) catalyzes the reaction
- N-substituted aminoacyl-tRNA + H2O [math]\displaystyle{ \rightleftharpoons }[/math] N-substituted amino acid + tRNA
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is aminoacyl-tRNA aminoacylhydrolase. Other names in common use include aminoacyl-transfer ribonucleate hydrolase, N-substituted aminoacyl transfer RNA hydrolase, and peptidyl-tRNA hydrolase.
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1RYB, 1WN2, 1XTY, 2D3K, 2E1B, 2PTH, 2Z2I, 2Z2J, and 2Z2K.
References
- "Enzymatic hydrolysis of N-substituted aminoacyl transfer ribonucleic acid in yeast". J. Biol. Chem. 244 (21): 5866–73. 1969. PMID 4981785.
![]() | Original source: https://en.wikipedia.org/wiki/Aminoacyl-tRNA hydrolase.
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